(see notes) Ovarian Cancer Follow-up: A Preliminary Comparison of 2 Approaches Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Thursday, December 22, 2016

(see notes) Ovarian Cancer Follow-up: A Preliminary Comparison of 2 Approaches

Blogger's Note: 'individualized? vs nurse-led vs conventional?; abstract does not define 'conventional' nor does trial;  view link to trial

trial:  A randomised study comparing satisfaction with follow up led by a trained cancer nurse versus conventional medical follow-up after primary treatment for ovarian cancer (UK)

trial: Intervention

1. Conventional medical follow up
2. Follow up care led by a trained cancer nurse 

Objective: The aim of the study was to perform a preliminary comparison of quality of life (QoL) and patient satisfaction in individualized nurse-led follow-up versus conventional medical follow-up in ovarian cancer.

Methods: One hundred twelve women who received a diagnosis of ovarian, fallopian tube, or peritoneal cancer, completed primary treatment by surgery alone or with chemotherapy, irrespective of outcome with regard to remission, and expected survival of more than 3 months. Fifty-seven participants were randomized to individualized follow-up and 55 patients to conventional follow-up. Well-being was measured at baseline and at 3, 6, 12, and 24 months after randomization for QoL (QLQ-C30 [European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire], QLQ-Ov28), the Hospital Anxiety and Depression Scale (HADS), and a Patient Satisfaction Questionnaire (PSQ-III). The primary endpoints were the effects of follow-up on each of the scores (via hierarchical mixed-effects model) and on relapse-free time (via Cox model). The total cost of follow-up was compared between each group.

Results: There was evidence for a QoL and patient satisfaction benefit for individualized versus standard follow-up. Hospital Anxiety and Depression Scale data provided no evidence in favor of either treatment. Delivered to protocol individualized follow-up resulted in a delay in the presentation of symptomatic relapse, although the effect on survival in this study is unknown. Cost was £700 lower on average for the individualized follow-up group, but the difference was not statistically significant at the 5% level.

Conclusions: Individualized follow-up was superior to conventional follow-up in 3 of the 4 QoL and patient satisfaction surveys in this preliminary study. Further prospective studies are needed in a larger population.

Trial registration number is ISRCTN59149551.


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