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Blog Archives: Nov 2004 - present
Special items: Ovarian Cancer and Us blog best viewed in Firefox
abstract
Infertility is a risk factor for ovarian cancer (OvCa). The goal was to
determine if antibodies to Selenium Binding Protein 1 (SBP1), an
autoantibody we identified in patients with premature ovarian failure
(POF), occurs in both infertility and OvCa patients, and thus could be
associated with preneoplasia. Anti-SBP1 was measured by immunoassay
against recombinant SBP1, in sera (blood) from OvCa (n=41), infertility (n=92)
and control (n=87) patients.
Therefore, anti-SBP1 occurs in infertile women
with POF, ovulatory disturbances or unexplained infertility and in
serous OvCa. This suggests an autoimmune process is associated with
development of serous OvCa.
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