Selenium Binding Protein 1 autoantibodies in ovarian disorders and ovarian cancer (infertility) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Thursday, December 15, 2016

Selenium Binding Protein 1 autoantibodies in ovarian disorders and ovarian cancer (infertility)



abstract

 Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to Selenium Binding Protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera (blood) from OvCa (n=41), infertility (n=92) and control (n=87) patients.
  Therefore, anti-SBP1 occurs in infertile women with POF, ovulatory disturbances or unexplained infertility and in serous OvCa. This suggests an autoimmune process is associated with development of serous OvCa.

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