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Showing posts with label BRCA1. Show all posts
Showing posts with label BRCA1. Show all posts
Friday, May 25, 2012

paywalled: Evolutionary Pathways in BRCAl-Associated Breast Tumors

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Evolutionary Pathways in BRCAl-Associated Breast Tumors Abstract BRCAl-associated breast tumors display loss of BRCA1 and frequent s...
Thursday, April 12, 2012

open access: A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome - study of 19 BRCA carriers

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A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome   ".......
1 comment:
Friday, April 06, 2012

BRCA 1/2 Decision Tool - Stanford Medicine Cancer Institute

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 Blogger's Note: variables can be changed eg. age/prophylactic surgery/s (type), easy to use, tip: hold your cursor over the chart to s...
Tuesday, April 03, 2012

open access: BRCA1 is an essential regulator of heart function and survival following myocardial infarction (in research, references doxorubicin)

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Blogger's Note : technical paper, in research (eg. mice, tissue samples)                           ~~~~~~~~~~~~~~~~~ BRCA1 is an ess...
Thursday, March 22, 2012

Marker of DNA Damage Could Predict Response to Platinum Chemotherapy

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Marker of DNA Damage Could Predict Response to Platinum Chemotherapy : Assay could direct treatment options for triple-negative br...
Wednesday, March 21, 2012

abstract: Clinical characteristics and outcomes of BRCA-associated ovarian cancer: genotype and survival.

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Clinical characteristics and outcomes of BRCA-associated ovarian cancer: genotype and survival Cancer Genet. 2012 Jan;205(1-2):34-41 Ab...
Friday, March 09, 2012

Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases. (300T>G mutation)

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Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases. : Limited signific...
Sunday, February 12, 2012

abstract: Age-Specific Incidence Rates for Breast Cancer in Carriers of BRCA1 Mutations from Norway (compared to Poland/North America)

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Clin Genet. 2012 Feb 9. doi: 10.1111/j.1399-0004.2012.01855.x. [Epub ahead of print] "Incidence rates of breast cancer among women...
Tuesday, January 17, 2012

Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers - abstract

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Abstract "Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide ...
Wednesday, August 03, 2011

Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1 Interacting Genes

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"Overall, the data suggest that genomic variation at multiple loci that encode proteins that interact biologically with BRCA1 are assoc...
Saturday, February 12, 2011

European Journal of Human Genetics - Abstract of article: On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

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"The BRCA1 mutation c.5266dupC was originally described as a founder mutation in the Ashkenazi Jewish (AJ) population. However, this ...
Thursday, September 16, 2010

abstract: A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas

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"Approximately 23% of unselected cases of breast cancer in the Bahamian population are attributable to a founder mutation in the BRCA1...
Wednesday, September 01, 2010

Preventive Surgeries Linked To Lower Risk Of Breast And Ovarian Cancer - BRCA mutations/international study

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news article: free full text/paper: http://jama.ama-assn.org/cgi/content/full/304/9/967 "Women who have in herited mutations inth...
Saturday, August 21, 2010

U of Toronto researcher discovers key protein involved in DNA repair Discovery gives insight into the way cells protect their own genetic material

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Note: in research "In a groundbreaking study, U of T researchers including Professors Daniel Durocher , Anne‐Claude Gingras and Fr...
Tuesday, August 17, 2010

Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations

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Abstract Mutations in the two breast cancer susceptibility genes BRCA1 and BRCA2 are associated with increased risk of breast and ovarian ...
Sunday, August 01, 2010

clinical trial: Attitudes About Childbearing And Fertility With Inherited Breast And Ovarian Cancer Syndromes (HBOC) - Full Text View - ClinicalTrials.gov

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Purpose Objectives: - To evaluate the attitudes and opinions of women undergoing genetic counseling for hereditary breast and ovari...
Monday, July 12, 2010

Cancer drug olaparib (PARP inhibitor) shows early promise | Philadelphia Inquirer (BRCA 1/2)

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Thursday, July 08, 2010

Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

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ABSTRACT Purpose The prevalence of BRCA1/2 mutations in germline DNA from unselected ovarian cancer patients is 11% to 15.3%. It is impo...
Wednesday, July 07, 2010

Testing for CHEK2 in the cancer genetics clinic: ready for prime time?

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Abstract Narod SA. Testing for CHEK2 in the cancer genetics clinic: ready for prime time? The 1100delC mutation of the CHEK2 gene was ...
Tuesday, July 06, 2010

BRCA1 mRNA expression and outcome to neoadjuvant cisplatin-based chemotherapy in bladder cancer — Ann Oncol

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Background: Neoadjuvant chemotherapy has shown a modest benefit in muscle-invasive bladder cancer patients; however, the subset of patien...