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Showing posts with label cancer genetics risks. Show all posts
Showing posts with label cancer genetics risks. Show all posts
Saturday, March 17, 2012

abstract: (Lynch Syndrome) Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA Mismatch Repair Gene Mutation: A Prospective Cohort Study [Epidemiology] multi-national study

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 Blogger's Note: some stats deleted for ease of reading, see abstract (or paid subscription for full details; interesting stat on femal...
Thursday, December 30, 2010

abstract: Ventral hernia following primary laparotomy for ovarian, fallopian tube, and primary peritoneal cancers

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An incisional hernia occurs in an area of weakness caused by an incompletely-healed surgical wound. Since median incisions in the abdomen ...
Monday, September 20, 2010

Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers (study of 173 BRCA mutation carriers)

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Objective To identify risk factors for the presence of a non-invasive lesion of the fallopian tube in women with a BRCA1 or BRCA2 mutati...
Tuesday, September 14, 2010

EvidenceUpdates - Bevacizumab (Avastin) increases risk for severe proteinuria in cancer patients including professional commentaries

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article link: http://plus.mcmaster.ca/EvidenceUpdates/NewArticles.aspx?Page=1&ArticleID=35795#Data abstract link: http://www.ncbi.nl...
Tuesday, August 17, 2010

abstract: A 67-Year-Old Woman with BRCA 1 Mutation Associated with Pancreatic Adenocarcinoma case report/discussion

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Abstract INTRODUCTION: There are approximately 40,000 new cases of pancreatic adenocarcinoma diagnosed in the USA each year. It is estimat...
Thursday, June 17, 2010

Cardiovascular Safety of VEGF-Targeting Therapies: Current Evidence and Handling Strategies -- Girardi et al., 10.1634/theoncologist.2009-0235 -- The Oncologist

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Abstract Treatment with the angiogenesis inhibitors bevacizumab, sunitinib, and sorafenib as single agents or in combination with convent...
Saturday, May 29, 2010

Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts

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BACKGROUND: Genetic screening of breast cancer patients and their families have identified a number of variants of unknown clinical s...
Tuesday, May 25, 2010

Attitudes Toward Information About Genetic Risk for Cognitive Impairment After Cancer Chemotherapy: Breast Cancer Survivors Compared With Healthy Controls

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Conclusion Results suggest lessened enthusiasm for genetic information that maintains or increases uncertainty about a specific course of ...
Saturday, May 22, 2010

Genetic/Familial High-Risk Assessment: Breast and Ovarian — J Natl Compr Canc Network NCCN

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Note : full free access; includes risks of Li-Fraumeni, Cowden and Lynch Syndromes
Tuesday, May 18, 2010

JCO -- Early Release CORRESPONDENCE Accrual Strategies for Cancer Genetics Research: Blurred Boundaries (ethics)

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CORRESPONDENCE   Accrual Strategies for Cancer Genetics Research: Blurred Boundaries Daniel Rayson and Karen A. Gelmon JCO published ...

Response to D. Rayson et al - re: Correspondence - Accrual strategies for cancer genetics research: blurred boundaries (ethics)

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Correspondence: Narod/Metcalfe: "If Drs Rayson and Gelmon1 are under the impression that we have influence over how the Globe and M...
Friday, May 14, 2010

Teal Toes: Women’s Health Week, Ovarian Cancer media/video - link between breast/ovarian cancers

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Note: no mention of other genetic risks aside from the BRCA's
Wednesday, May 12, 2010

abstract: The inherited genetics of ovarian and endometrial cancer

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"Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast,...
Tuesday, May 11, 2010

full access: Knowledge, attitudes, and clinical experience of physicians regarding preimplantation genetic diagnosis for hereditary cancer predisposit

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Note : for full free access click on 'pdf'
Wednesday, April 14, 2010

What keeps you up at night? Genetics professionals' distressing experiences in patient care

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Abstract  PURPOSE:   To explore specific patient care experiences that genetics professionals associate with distress and the emotions eng...
Tuesday, March 30, 2010

Myriad Loses Ruling Over Breast Cancer-Gene Patents (Update3) - BusinessWeek news article March 29, 2010

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"The case is sure to be appealed to a court in Washington that specializes in patent law, and most likely to the Supreme Court..... ...
Friday, March 12, 2010

Breast cancer susceptibility variants alter risks in familial disease -- Latif et al. 47 (2): 126 -- Journal of Medical Genetics

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"Conclusions: This study confirms that susceptibility variants in FGFR2, TOX3 and MAP3K1 and on chromosome 8q are all associated with ...
Wednesday, February 24, 2010

JCO - Relationship Between Plasma Estradiol Levels and Estrogen-Responsive Gene Expression in Estrogen Receptor-Positive Breast Cancer in Postmenopausal Women UK/US study

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Purpose To determine whether plasma estradiol (E2) levels are related to gene expression in estrogen receptor (ER)–positive breast cancers i...
Friday, February 19, 2010

PLoS Genetics: Use of DNA–Damaging Agents and RNA Pooling to Assess Expression Profiles Associated with BRCA1 and BRCA2 Mutation Status in Familial Breast Cancer Patients

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definition: heterogeneous - the quality of being diverse and not comparable in kind full access: "A large number of rare sequence...
Thursday, February 18, 2010

YouTube - Insidermedicine In Depth - February 8, 2010 - combination Paxil/Tamoxifen + clinical commentary

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