Monday, November 10, 2008
Highlights on an Invitational Exchange Fall 2008 The Change Foundation
Lessons & Confessions from the Regional Health-care Front: Where can they lead Ontario?
May 2008
Confessions_Web.pdf (application/pdf Object)
Advice and admonitions for Ontario:
Support leaders who stand alone, take the heat, bear
the pain, and tell the truth.
A statement for extensive primary cytoreductive surgery in advanced ovarian cancer (references CHORUS trial)
Wiley InterScience :: Article :: HTML Full Text
The support that this trial and its European counterpart received suggests to us that there are many like-minded gynaecological oncologists who wish to see our management strategies for ovarian cancer based on evidence and not historical practice.
Virtual Posters: Health-Related Quality of Life in Ovarian Cancer: methodological issues in Randomised Controlled Trials
Virtual Posters
Conclusions
Lack of clear reporting of trial withdrawals and inappropriate statistical methods for handling missing data and informative censoring are predominant in the ovarian cancer trial literature. This may bias results and limit information in understanding disease impact and any therapeutic treatment benefits. Future trials should focus on these methodological limitations and a priori definitions of minimally important differences in HRQOL outcomes.
Sunday, November 09, 2008
e-Health: educating, enlightening, or exasperating the American patient with cancer? (NCCN 2008)
e-Health: educating, enlightening, or exasperating the American patient with cancer? (NCCN 2008): "“One of the problems is that cancer is not a sound bite,” argued Al B. Benson III, MD, of the Robert H. Lurie Comprehensive Cancer Center. “It is a complex collection of diseases with very complex biology. And it’s impossible for a lay population to fully grasp all of those nuances.”"
We Fought Cancer…And Cancer Won
We Fought Cancer…And Cancer Won
"....Stop us if you've heard that before. Hope springs eternal that such findings will not join the long list of those that are interesting but irrelevant to patients."
Tuesday, November 04, 2008
Monday, November 03, 2008
Information exchange among physicians caring for the same patient in the community - Canadian Medical Association Journal
Information exchange among physicians caring for the same patient in the community -- van Walraven et al. 179 (10): 1013 -- Canadian Medical Association Journal:
"Conclusion
Our study has revealed poor exchange of information between physicians who treat the same patient in the community. If continuity of patient care is to be increased, interventions and systemic modifications will be needed to improve information exchange.
UICC - Sign the World Cancer Declaration 2008
uicc | international union against cancer - A call to action from the global cancer community
Together we can eliminate cancer as a major threat for future generations
Sign the World Cancer Declaration 2008
Let your voice be heard!
Your endorsement will show the world's leaders that the global cancer community stands united behind this for call for action to reduce the global cancer burden significantly by 2020.
- Click here to sign the declaration online as an individual and here to see the individual signatories
- Click here to endorse the declaration online as an organization and here to see the organizational signatories
- Click here to read the call to action or here to download the pdf
The World Cancer Declaration 2008 is a tool to help cancer advocates bring the growing cancer crisis to the attention of health policymakers at national, regional and global levels.
It represents a consensus between foundations, national and international non-governmental and governmental organizations, professional bodies, the private sector, academia and civil society from all continents that are committed to the vision of eliminating cancer as a major threat for future generations.The UICC encourages partnership within the framework of the World Cancer Declaration. By working together, we can more easily implement the priority actions and achieve the 2020 targets.
Note: Organizations should endorse the call only once
abstract: I am doing the best that i can!
Editorial commentary (mine): interesting the small cap "i":
I am doing the best that i can!
"The qualitative nature of this study provides the 'voice' of women who have a GI disorder, which is often lacking in the literature, thus providing healthcare professionals with insight into the feelings and experiences of these women. The inability to understand the experiences of individuals with chronic conditions can act as a barrier in the treatment and interaction/rapport between healthcare professional and client."
The antidepressant debate and the balanced placebo trial design: An ethical analysis
The antidepressant debate and the balanced placebo...[Int J Law Psychiatry. 2008] - PubMed Result
abstract: Int J Law Psychiatry. 2008 Oct 25
The antidepressant debate and the balanced placebo trial design: An ethical analysis.
Waring DR.
York University, Toronto, Canada.
"...My focal question is whether the BPTD is ethically defensible. I will explore two objections that can be raised against it: 1) lying to BPTD research subjects violates their autonomy and exploits their illness and 2) the BPTD may not enable us to test the additivity thesis with accuracy, i.e., it may contribute to the masking of drug effects that it aims to avoid. I argue that these objections support the conclusion that the BPTD is ethically indefensible."
abstract: The Potential of PARP Inhibitors in Genetic Breast and Ovarian Cancers
Wiley InterScience :: JOURNALS :: Annals of the New York Academy of Sciences: "The Potential of PARP Inhibitors in Genetic Breast and Ovarian Cancers"
Sunday, November 02, 2008
Informed Consent Revisited: A Doctrine in the Service of Cancer Care - The Oncologist
Informed Consent Revisited: A Doctrine in the Service of Cancer Care -- Schachter and Fins 13 (10): 1109 -- The Oncologist
Empathetic and attentive interest in patients facilitates an understanding about patients' physiological and psychological needs. Significantly, it enables the physician to contextualize the patient's decision within the patient's moral and values framework. If there is a paradox in all of this, it is that the ideal of informed consent rests as much in the physician educating the patient as it does in the patient educating the physician.
The Edmonton symptom assessment system-what do patients think? [Support Care Cancer. 2008]
The Edmonton symptom assessment system-what do pat...[Support Care Cancer. 2008] - PubMed Result
"Patients expressed a need to emphasize the timeframe as 'now'."
Interval debulking surgery for advanced epithelial ovarian cancer
Interval debulking surgery for advanced epithelial ovarian cancer
Plain language summary
Interval debulking surgery for advanced epithelial ovarian cancer
"Ovarian cancer frequently presents at an advanced stage so it may not be possible to surgically remove all the tumours. Several cycles of chemotherapy are generally given after primary surgery. Secondary surgery, performed after a few cycles of chemotherapy before proceeding to further cycles of chemotherapy, is called interval debulking surgery (IDS). This review compared the survival of patients with advanced epithelial ovarian cancer, who had IDS performed between cycles of chemotherapy after primary surgery with survival of patients who had conventional treatment (primary debulking surgery and adjuvant chemotherapy). It found similar survival in patients who did and did not receive IDS. No adequate information regarding adverse effects was available. Data on quality of life (QOL) of the patients were also inconclusive."
The American Journal of Surgical Pathology - Abstract: Volume 32(11) November 2008 p 1667-1674 Subdividing Ovarian and Peritoneal Serous Carcinoma Into Moderately Differentiated and Poorly Differentiated
Subdividing Ovarian and Peritoneal Serous Carcinoma Into Moderately Differentiated and Poorly Differentiated Does not Have Biologic Validity Based on Molecular Genetic and In Vitro Drug Resistance Data.
free full text: Loss of DNA Mismatch Repair Protein hMSH6 (one Lynch Syndrome gene) in Ovarian Cancer is Histotype-Specific
Loss of DNA Mismatch Repair Protein hMSH6 in Ovarian Cancer is Histotype-Specific
Conclusions:
These results underscore the importance of identifying the correct HNPCC-associated tumors and genes toward the recognition of affected families that may develop ovarian carcinoma as well as appropriate clinical surveillance. We found negative hMSH6 protein expression in several histologic subtypes of ovarian carcinoma, particularly in clear cell, endometrioid, and mucinous carcinoma, suggesting that loss of hMSH6 function may participate in the genesis of these subtypes of cancer. However, loss of hMSH6 protein expression did not predict overall survival, and it was not associated with disease stage, tumor grade, patient age or family history of cancer.
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