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Tuesday, September 04, 2012

Hospital readmission rates under the microscope




CMAJ September 4, 2012 vol. 184 no. 12 
  • News

Hospital readmission rates under the microscope

Author Affiliations
  1. CMAJ

Although hospital readmission rates cost the health care system as much as $1.8 billion per year, there's no need for Canada to follow the United States' lead and impose penalties on facilities for failing to implement measures to reduce readmissions, Canadian experts say.

The incidence and causes of preventable readmissions are so unclear that measures to reduce readmission rates are premature, if not unwarranted, argues Dr. Carl van Walraven, senior scientist in the Clinical Epidemiology Program at the Ottawa Health Research Institute and associate professor in the Department of Epidemiology and Community Medicine at the University of Ottawa in Ontario.

"Before we start focusing on trying to address a statistic, we need to first truly understand the meaning of the statistic. If my hunch is correct that the vast, vast majority of readmissions are unavoidable, then coming up with policies and procedures to influence a statistic that has a very marginal association with quality of care is not in our best interest," he says.

The Canadian Institute for Health Information recently estimated that roughly 8.5% of patients are readmitted to hospital within 30 days (https://secure.cihi.ca/free_products/Readmission_to_acutecare_en.pdf). An estimated 9%–59% of those readmissions could be avoided by better identifying those most likely to return to hospital within short periods and improving the care they receive before and after discharge (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-4248).

By contrast, an estimated 20% of Medicare (which provides health services to the elderly) patients in the United States are readmitted within 30 days, at a cost of US$12 billion per year, prompting American legislators to implement penalties on facilities if patients are readmitted to a hospital for heart failure, acute myocardial infarction or pneumonia within that 30-day period.

Under the Hospital Readmissions Reduction Program, which takes effect in October 2012, hospitals stand to lose up to 1% of their net inpatient Medicare payments if their readmissions are above an established baseline rate. The penalty cap will rise to 2% in 2014 and 3% in 2015.

Figure

If you see this sign twice in one month, you may be among the estimated 8.5% of Canadian patients who are readmitted to a hospital within 30 days of being discharged.

Image courtesy of © 2012 Thinkstock

The level of penalty will be determined using a formula that calculates each hospital's "excess readmission ratio" relative to national average readmission rates from the period July 2008 to June 2011 (http://cms.gov/Medicare/Medicare-Fee-for-Service-Payment/AcuteInpatientPPS/Readmissions-Reduction-Program.html/). Discharging hospitals will be penalized even if the patient is admitted to a different facility, but the formula does include an adjustment for demographic considerations, "comorbidities, and patient frailty."

The aim was to nudge hospitals into improving the quality of their care. To that end, the US Agency for Healthcare Research and Quality was asked to develop "readmission reduction practice recommendations."

Those included improving transitional care by following up with patients post-discharge and providing them with "comprehensive post-discharge instructions on medications, self-care, and symptom recognition and management," as well as the use of a hospital discharge program that "re-engineers the workflow process" (www.ahrq.gov/news/kt/red/readmissionslides/readslides-contents.htm).

But using readmission rates as an indicator of quality of care is a dubious proposition, van Walraven says in arguing against the need for similar measures in Canada.

"The key question is how strongly does a readmission to hospital reflect quality of care and how strongly does it just reflect a sick person," adds van Walraven, who concluded in a systematic review of 34 studies that measured the proportion of hospital readmissions classified as avoidable that there is "a lack of consensus regarding the methods necessary to judge whether readmissions are avoidable" (www.cmaj.ca/lookup/doi/10.1503/cmaj.101860). "All but three of the studies used subjective criteria to determine whether readmissions were avoidable," states the study, which concluded that "the true proportion of hospital readmissions that are potentially avoidable remains unclear."

Others argue that the solution to the problem of high hospital readmission rates lies in systemic reform.

Preventable readmissions are more likely a systems issue than the result of errors, says Dr. Irfan Dhalla, assistant professor in the Department of Medicine and Health Policy, Management and Evaluation at the University of Toronto in Ontario and scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital. "If you had an integrated health system where primary care, home care, pharmacy and the hospital were all integrated, it probably would make sense to hold that integrated health system accountable in some manner for its readmission rates … but we don't have an integrated health care system; we have a fragmented health care system."

Canada's unintegrated system is poorly suited for treating patients with complex issues, Dhalla says. "We each operate in our own little silos and we do a very good job completing our own charts, but we don't share our information as readily as we might with all of the other people who are helping take care of an individual patient."

For its part, the Canadian Healthcare Association says the best course of action will only emerge from further research. "We really do need to continue to improve our data collection so we really can tell what the situation is," says Pamela Fralick, president and CEO of the association. "Can we eventually tease out what percentage of the readmissions are avoidable? That's the key question."




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Palliative care subspecialty in the offing - CMAJ



Palliative care subspecialty in the offing

Author Affiliations
  1. CMAJ

An aging population, a tide of chronic disease and spotty access to quality end-of-life care makes the establishment of palliative medicine as a subspecialty, and certification of family physicians with added competence in palliative medicine, logical steps in the provision of care to Canadians, experts contend.

Now in the offing, the changes will ultimately result in bolstered capacity to serve societal needs, says Dr. Cori Schroder, cochair of the Royal College of Physicians and Surgeons of Canada and the College of Family Physicians of Canada Conjoint Advisory Committee on Palliative Medicine. "I think the bottom line is that this is going to promote more accessible and more complete care for a broadening patient population."

A two-year subspecialty program in palliative medicine is currently under consideration for approval by the Royal College of Physicians and Surgeons of Canada, while the College of Family Physicians of Canada is drafting the criteria under which a certificate of added competence in palliative medicine should be awarded.

The growing number of elderly patients with chronic conditions and expanding demand for palliative care has spurred calls for more training of physicians in end-of-life care (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-4223). Studies have also indicated that access to high-quality end-of-life care varies substantially across the nation (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-3763).

Creation of a subspecialty and certification of family doctors with competence in the provision of palliative care, in tandem, would be a definite boon to the delivery of palliative care in Canada, says Dr. Sandy Buchman, president of the College of Family Physicians of Canada. There is a need for physicians with expertise or enhanced skills in palliative medicine, particularly when it comes to the handling of patients with complex combinations of diseases, he explains.

Figure

An aging population and a tide of chronic disease mean more Canadians need a helping hand, leading to increased demand for palliative care services and expertise.

Image courtesy of © 2012 Thinkstock

Moreover, history suggests that advances in the provision of a service such as palliative medicine require such specialization and certification, says Dr. Joshua Shadd, an assistant professor in the Department of Family Medicine at the Schulich School of Medicine & Dentistry at Western University in London, Ontario. "The generalist can't be expected to advance the field."

While a one-year program of added competence in palliative medicine jointly accredited by the Royal College of Physicians and Surgeons of Canada and the College of Family Physicians of Canada has been offered by various Canadian medical schools since 1999, it has not resulted in specialist recognition or any manner of certification.

The proposed two-year subspecialty, by contrast, will result in recognition, Dr. Deborah Dudgeon, cochair of the conjoint advisory committee, writes in an email. Admittance to palliative subspecialty training would typically follow completion of specialty training in internal medicine, neurology, anaesthesia or pediatrics but a practice-eligible route is also under consideration, though the parameters have yet to be defined, she adds.

It's expected that subspecialty training will consist of two streams — adult and pediatric — that would aim to equip physicians with such core competencies as the ability to assess and manage pain and to address psychological, social, spiritual and existential issues that might arise when treating patients.

Meanwhile, certification of family doctors with added competence in palliative care being hashed out by the College of Family Physicians of Canada is part of a move to bring the growing number of physicians with special interests (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-4040) back into the fold of comprehensive care (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-4036). In June, the college's board of directors approved the development of criteria for the awarding of a certificate of added competence with or without a special designation in palliative care, sport and exercise medicine, anaesthesia, emergency medicine and care of the elderly (www.bccfp.bc.ca/Highlights_CFPC%20Board%20of%20Directors%20Meeting%20June%202012.pdf).

Currently, emergency medicine is the only branch allowed special designation by the College of Family Physicians of Canada.

Buchman says such a designation would be beneficial as it would allow for greater recognition of family doctors who do extra studies and work in the area of palliative medicine. But the risk is that this move may unintentionally communicate to graduating family physicians that additional certification is required to be competent to provide such palliative services, he adds. "We don't want to give that message at all."

Some issues still need to be ironed out in the creation of a subspecialty of palliative medicine and certification of family doctors with expertise in the area, notes Dr. Doris Barwich, president of the Canadian Society of Palliative Care Physicians.

It had been hoped that a subspecialty could be created that would be accessible from both the Royal College of Physicians and Surgeons of Canada and College of Family Physicians of Canada streams but that didn't pan out because of the colleges' disparate missions, Barwich says, adding that care will be required going forward to prevent a two-tiered outcome. "Our history is that we've been able to do this collaboratively and jointly, but now that both colleges are defining a different way forward, there's work for us to do to make sure that doesn't split the profession."




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Palliative care training substandard CMAJ




Palliative care training substandard

Author Affiliations
  1. CMAJ

Most of the hundreds of thousands of Canadians who die each year from natural causes spend their final days under the care of family doctors and nurses. Many experts in end-of-life care question whether these caregivers have the skills necessary to ensure dying patients meet peaceful ends, and are calling for more palliative experts and increased training for all physicians.

To that end, efforts have been initiated to create a subspecialty in palliative medicine, but experts say there's still a need for more core training of all physicians about its nuances.

"I think that palliative care is similar to, say, cardiology, where all physicians, all nurses and health care professionals need to have a base level of knowledge in order to manage most of the issues of patients," says Dr. Deborah Dudgeon, cochair of the Royal College of Physicians and Surgeons of Canada and the College of Family Physicians of Canada Conjoint Advisory Committee on Palliative Medicine. "But once things get a bit more complex, then there needs to be another one or two levels of expertise that can support people so that they can get optimal care."

Numerous studies have shown there are significant variations in the quality of palliative care that Canadians receive (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-3763). The Canadian Hospice Palliative Care Association has found that access to palliative care was very much a matter of luck of the draw (www.chpca.net/resource_doc_library/HPC_Policy_Brief_Systems_Approach_June_2010.pdf), while the Quality End-of-Life Care Coalition of Canada found that "the gap between what Canadians want at the end of life and what they experience has been due, in part, to the variability in the hospice palliative care services provided at home in different jurisdictions" (www.chpca.net/qelccc/hphc-progress_report/Hospice_Palliative_Home_Care_Progress_Report-final.pdf).

Retired Liberal senator Sharon Carstairs, a long-time crusader for improved end-of-life care, noted in a report, Raising the Bar: A Roadmap for the Future of Palliative Care in Canada, that "there are still Canadians dying in needless pain because health care providers do not know what a good death is" (www.virtualhospice.ca/Assets/Raising%20the%20Bar%20June%202010_Senator%20Sharon%20Carstairs_20100608160433.pdf).

Figure

Research suggests people would prefer to die at home while receiving appropriate end-of-life care, but most Canadians still die in primary care without assistance from palliative care experts.

Image courtesy of © 2012 Thinkstock

Although studies repeatedly show that most people would prefer to die at home while receiving appropriate end-of-life care, that's generally not the norm.

"The bottom line is 65% of all Canadians die in primary care," says Sharon Baxter, executive director of the Canadian Hospice Palliative Care Association. "They don't have a palliative care physician or social worker engaged."

The aging of Canada's population will make the need for better trained health care providers that much more critical in the future, the association says (www.chpca.net/media/7622/fact_sheet_hpc_in_canada_may_2012_final.pdf). Others, including the Canadian Geriatric Society, have argued that the need is so compelling that the provision of geriatric training for undergraduate medical students should be a condition of accreditation of medical schools, as well as a competency tested on licensing exams (www.cmaj.ca/lookup/doi/10.1503/cmaj.109-4195).

Demand for palliative care is rising because there are more elderly patients with chronic conditions and more illnesses that require such treatment, experts say. "We've been traditionally focused on patients with cancer," says Dr. Cori Schroder, cochair of the Royal College of Physicians and Surgeons of Canada and the College of Family Physicians of Canada Conjoint Advisory Committee on Palliative Medicine. "We now are looking after people with congestive heart failure, with respiratory difficulties, with ALS [amyotrophic lateral sclerosis], people who are on dialysis."

Some steps have been taken to bolster the ranks of experts and increase the baseline knowledge of all health care providers. Although defunct, the Educating Future Physicians in Palliative and End-of-Life Care (EFPPEC) program developed six core competencies: management of pain and symptoms, such as through evidence-based opioid strategies; response to psychosocial and spiritual needs; assistance in end-of-life decision-making and planning; effective communication with patients and families; interdisciplinary collaboration; and easing the suffering of terminally ill patients (www.afmc.ca/efppec/docs/pdf_2008_efppec_core_competencies_en.pdf). As a result of the program, those competencies must be integrated in some form into the curricula of Canadian undergraduate medical schools, though no specifics are prescribed on how that content is expressed.

Translation of those competencies into curricula has been checkerboard, Schroder writes in an email. "Since EFPPEC, there has been some improvement in the knowledge, skills and attitudes of graduating medical students regarding palliative and end-of-life care but it is still less than adequate as the 'translation' into curriculum is variable across Canada."

More research would be needed to determine how effectively the competencies are being reflected in medical school curricula, says Dr. Larry Librach, Sun Life Financial chair in bioethics and director of the Joint Centre for Bioethics at the University of Toronto in Ontario and past director of the Temmy Latner Centre for Palliative Care at Mount Sinai Hospital in Toronto. Palliative care education in postgraduate medical schools remains sparse, he says. "We'd like to think that the enhanced curriculum does produce better physicians, but the postgraduate side of things needs to complement what they're seeing in the undergraduate and doing in the undergraduate."

For existing health care practitioners looking to acquire advanced skills, various Canadian medical schools offer a one-year program of added competence in palliative medicine for medical graduates jointly accredited by the Royal College of Physicians and Surgeons of Canada and the College of Family Physicians of Canada. Nurses can opt for certification in palliative care through the Canadian Nurses Association.

Recognizing palliative medicine as a subspecialty would doubtlessly have a major impact on bolstering training in the field, says Dudgeon. To that end, the Royal College of Physicians and Surgeons of Canada is considering a two-year subspecialty in palliative medicine. The Royal College's Committee on Specialties approved the notion and it's hoped it will be finalized within a year, Dudgeon adds. As well, the College of Family Physicians of Canada is developing the criteria for a one-year certification program in palliative medicine.

Subspecialization in palliative medicine would offer several benefits, Schroder says. Specialists would be more readily able to treat complex cases, contribute to research on palliative medicine and help train the next generation of physicians in palliative care.

But ensuring that all physicians nationwide are adequately trained in palliative care will require "some push from above" (i.e., government policies and resources), as well as public demand for quality end-of-life care, says Librach. "It's really going to require a top-down approach and it's going to require institutions that say quality end-of-life care is as important to us as quality birthing care or quality of care in the emergency department."



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Hand-wringing over handwashing -CMA/Patient Safety



http://www.cmaj.ca/content/184/12/E631.short?rss=1


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Educators propose “flipping” medical training



http://www.cmaj.ca/content/184/12/E625.short?rss=1


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Stopping clinical trials early for futility: retrospective analysis of several randomised clinical studies PDF



http://www.nature.com/bjc/journal/v107/n6/pdf/bjc2012344a.pdf


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JCI - HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts



http://m.jci.org/articles/view/62229?key=b6ff63068b5ca3f2ed18


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Ovarian cancer cells hijack surrounding tissues to enhance tumor growth



http://www.sciencedaily.com/releases/2012/09/120904121436.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fovarian_cancer+%28ScienceDaily%3A+Health+%26+Medicine+News+--+Ovarian+Cancer%29&utm_content=Google+Reader


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NIH Director announces appointment of Janine Clayton as Director of the Office of Research on Women's Health (ORWH) and the Associate Director for Research on Women’s Health, September 4, 2012 News Release - National Institutes of Health (NIH)



NIH Director announces appointment of Janine Clayton as Director of the Office of Research on Women's Health (ORWH) and the Associate Director for Research on Women's Health





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NEWS-OHA- Open Data, Big Data, Yes...but NOT Personal Data: Distinguished Speaker Series



http://www.ohatoday.com/News/Pages/NEWS-08302012-OpenDataBigData.aspx


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Health News Watchdog on ethics of commercial screening tests



AUG2012



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BMC Complementary and Alternative Medicine | Full text | Alternative Health Care Consultations in Ontario, Canada: A Geographic and Socio-Demographic Analysis



http://www.biomedcentral.com/1472-6882/11/47


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Patient safety law protects some documents in court case - amednews.com



http://www.ama-assn.org/amednews/2012/08/27/prsd0829.htm


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Conservative management of early-stage epithelial ovarian cancer: results of a large retrospective series




Conservative management of early-stage epithelial ovarian cancer: results of a large retrospective series

Background

To assess the long-term oncological outcome and the fertility of young women with early-stage epithelial ovarian cancer (ES/EOC) treated with fertility-sparing surgery (FSS).

Patients and methods

All patients treated with FSS for ES/EOC in two Italian centers were considered for this analysis. Univariate and multivariate analyses were used to test demographic characteristics and clinical features for the association with overall survival (OS), recurrence-free survival (RFS) and fertility.

Results

From 1982 to 2010, 240 patients with malignant ES/EOC were treated with FSS in two tertiary centers in Italy. At a median follow-up of 9 years, 27 patients had relapsed (11%) and 11 (5%) had died of progressive disease. Multivariate analysis found only grade 3 negatively affected the prognosis of patients [hazard ratio (HR) for recurrence: 4.2, 95% confidence interval (CI): 1.5–11.7, P = 0.0067; HR for death: 7.6, 95% CI: 2.0–29.3, P = 0.0032]. Grade 3 was also significantly associated with extra-ovarian relapse (P = 0.006). Of the 105 patients (45%) who tried to become pregnant, 84 (80%) were successful.

Conclusions

Conservative treatment can be proposed to all young patients when tumor is limited to the ovaries, as ovarian recurrences can always be managed successfully. Patients with G3 tumors are more likely to have distant recurrences and should be closely monitored.



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Identification of the optimal pathway to reach an accurate diagnosis in the absence of an early detection strategy for ovarian cancer.




Identification of the optimal pathway to reach an accurate diagnosis in the absence of an early detection strategy for ovarian cancer.


Identification of the optimal pathway to reach an accurate diagnosis in the absence of an early detection strategy for ovarian cancer.


Gynecol Oncol. 2012 Aug 29;


Authors: Hess LM, Stehman FB, Method MW, Weathers TD, Gupta P, Schilder JM


Abstract

OBJECTIVES: There is a lack of knowledge about the health care events experienced by individual patients that lead to a definitive diagnosis of ovarian cancer (OC). The goal of this study was to describe the various pathways and to identify an optimal path to accurate diagnosis. METHODS: Women who were referred to gynecologic oncology for a suspected OC were enrolled to this study. Medical records (MRs) from all health care providers were obtained from the time the patient recalled first suspecting a health issue through the time of diagnosis to build a decision tree model. A Monte Carlo simulation was conducted of 83,000 patients to identify the optimal pathway to reach diagnosis. RESULTS: In the Monte Carlo simulation, gynecologic oncologists and gynecologists accounted for the most efficient diagnosis in over 37.9% and 29.2% of suspected OC cases, respectively, in terms of the least amount of time to reach diagnosis. Gynecologic oncologists were further associated with the fewest health care visits needed to reach diagnosis in 37% of the simulation cases; however, 23% of trials were indifferent to any specific provider. CONCLUSIONS: The decision tree provides a more comprehensive view of the complexity in reaching an accurate diagnosis of OC. This analysis was able to identify the health care utilization patterns that underlie the events that occur to reach an accurate diagnosis in the setting of a suspected OC, and was able to identify the most efficient pathways that utilize the fewest health care resources in the least amount of time.

PMID: 22940492 [PubMed - as supplied by publisher]



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Elderly and very elderly advanced ovarian cancer patients: Does the age influence the surgical management?




Elderly and very elderly advanced ovarian cancer patients: Does the age influence the surgical management?


Elderly and very elderly advanced ovarian cancer patients: Does the age influence the surgical management?


Eur J Surg Oncol. 2012 Aug 28;


Authors: Fanfani F, Fagotti A, Salerno MG, Margariti PA, Gagliardi ML, Gallotta V, Vizzielli G, Panico G, Monterossi G, Scambia G


Abstract

BACKGROUND: To examine the surgical treatment and clinical outcome of elderly and very elderly advanced epithelial ovarian cancer patients. METHODS: We retrospectively analyzed FIGO stage IIIC-IV ovarian cancer patients, divided in elderly (Group A, >65 and <75 years) and very elderly patients (Group B, ≥75 years) treated by primary debulking surgery (PDS) or by interval debulking surgery (IDS) at the Catholic University at Rome and Campobasso, Italy. RESULTS: 164 patients were included: 123 (Group A) and 41 (Group B). Complete cytoreduction was achieved in 60 patients (60.6%) in Group A and in 20 patients (62.5%) in Group B (p = 0.75). In the remaining cases, optimal cytoreduction was performed (39 cases (39.4%) in Group A and 12 (37.5%) in Group B; p = 0.75). In Group A complete/optimal debulking was achieved in 53 patients (53.5%) at PDS and in 46 patients (46.5%) at IDS (p = 0.55). In the Group B a higher rate of patients was debulked at IDS with respect to PDS (10 (31.3%) vs. 22 patients (68.7%); p = 0.02). In Group A patients debulked at PDS showed better DFS (p = 0.007) and OS (p = 0.003) with respect to patients submitted to successful IDS, whereas in group B we did not observed any survival difference according to time of cytoreduction. CONCLUSIONS: Our data suggest that elderly and very elderly patients may tolerate radical and ultra-radical surgery. These patients should be managed in a gynecologic oncology unit, with prudent but complete approach.

PMID: 22939013 [PubMed - as supplied by publisher]



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Prolonged postoperative venous thrombo-embolism prophylaxis is cost-effective in advanced ovarian cancer patients.




Prolonged postoperative venous thrombo-embolism prophylaxis is cost-effective in advanced ovarian cancer patients.


Prolonged postoperative venous thrombo-embolism prophylaxis is cost-effective in advanced ovarian cancer patients.


Gynecol Oncol. 2012 Aug 29;


Authors: Uppal S, Hernandez E, Dutta M, Dandolu V, Rose S, Hartenbach E


Abstract

OBJECTIVE: The purpose of this study was to investigate the cost-effectiveness of prolonged prophylaxis with enoxaparin in high-risk surgical patients with ovarian cancer. In addition, we sought to quantify the impact of prolonged prophylaxis (PP) on the incidence of venous thromboembolism (VTE), its related complications, and overall patient survival. METHODS: A Markov decision analytic model was used to estimate the costs, resource allocation and outcomes associated with the prolonged use of enoxaparin, for a total of four weeks after surgery, in patients undergoing primary debulking surgery for stage IIIC ovarian cancer. We estimated incremental cost per quality-adjusted life-year (QALY) at one and five year intervals; the estimated reduction in VTE episodes, bleeding episodes, and survival at the five year interval for a simulated cohort of 10,000 women. RESULTS: The incremental cost effectiveness ratio (ICER) for prolonged prophylaxis (PP) was $5236/QALY and $-1462/QALY at one and five years respectively. For patients receiving PP, the model estimated a 12% reduction in the clinically evident VTE episodes and a higher five-year survival (31.61% vs. 29.96%; p<0.0001). Resource allocation analysis reveals that 95% of initial investment cost of prolonged enoxaparin is recovered within one year. CONCLUSIONS: In ovarian cancer patients undergoing open abdominal surgery, prolonged VTE prophylaxis not only improves patient outcomes, but is also a cost saving strategy when modeled over five years. A significant reduction in the episodes of VTE and a higher overall survival warrants consideration for the routine use of PP in this patient population.

PMID: 22940486 [PubMed - as supplied by publisher]



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Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.




Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.

Related Articles

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.


Fam Cancer. 2012 Sep 1;


Authors: Crobach S, van Wezel T, Vasen HF, Morreau H


Abstract

Metastases to the ovary occur in 0.8-9.7 % of colorectal cancer (CRC) cases (Hanna and Cohen in Clin Colorectal Cancer 3(4):215-222, 2004). The need to combine surgical resection of the primary tumor and bilateral oophorectomy is a matter of debate (Erroi et al. in J Surg Oncol 96(2):113-117, 2007). In a consecutive multi-hospital cohort of 30 CRC metastases to the ovary we came across four female patients (13 %; 95 % CI 3.6-34.1) with familial adenomatous polyposis (FAP). This number is high since the estimated incidence of FAP CRC is far below 1 % of all CRC and the expected incidence of FAP CRC that metastasized to the ovaries would thus be almost zero. In a second screen in nationwide databases we found that ovarian metastases occurred in at least 15 % of female FAP CRC cases. We provide now first evidence that especially in female FAP CRC patients bilateral oophorectomy during surgery should be discussed.

PMID: 22941256 [PubMed - as supplied by publisher]



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Walking a tightrope: oncologists' perspective on providing information to women with recurrent ovarian cancer (ROC) during the medical encounter.




Walking a tightrope: oncologists' perspective on providing information to women with recurrent ovarian cancer (ROC) during the medical encounter.

PURPOSE: Women with ovarian cancer (OC) must make treatment decisions. The first step in this process involves information giving about potential management choices. In this study, our objectives were to (1) describe the key issues that are reviewed by the oncologist when a woman presents with recurrent OC and (2) understand the extent to which physicians have different methods of giving information to patients. METHODS: A descriptive qualitative study of 19 gynecologic and medical oncologists in Ontario, Canada was undertaken using a semi-structured interview guide. RESULTS: Oncologists felt that the process of information giving was an important part of the medical encounter. The main themes that emerged from our data were (1) Oncologists varied in their approach to giving information about the disease and management; (2) oncologists felt that giving management choices to the patients helped engage patients in dealing with their disease and moving forward; (3) oncologists felt it was important to foster patient's hope; and (4) oncologists struggled with how much clinical outcome information to give to patients. CONCLUSIONS: Oncologists tried to achieve a difficult balance between providing patients with several management choices in order to help them keep hope alive and providing them with realistic clinical information suggesting poor patient outcomes. Areas for future research include exploring (1) how physicians can best walk this tightrope of information giving, (2) how to assess physician "success" in doing so, and (3) the meaning of fostering hope to patients and physicians in the context of treatment decision making.


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Gene expression microarray-based assay to determine tumor site of origin in a series of metastatic tumors to the ovary and peritoneal carcinomatosis of suspected gynecologic origin.




Gene expression microarray-based assay to determine tumor site of origin in a series of metastatic tumors to the ovary and peritoneal carcinomatosis of suspected gynecologic origin.



Journal

Hum Pathol. 2012 Aug 30

Abstract

The origin of the primary tumor is sometimes difficult to determine in peritoneal and ovarian metastases. A series of 25 metastatic tumors to the ovary and 7 cases of peritoneal carcinomatosis of suspected gynecologic origin were collected. Total RNA was extracted from frozen tumor tissue and studied by the Tissue of Origin-Frozen test, a microarray-based gene expression test from Pathwork Diagnostics (Redwood City, CA). Independently, formalin-fixed, paraffin-embedded tumor tissue was subjected to pathologic analysis. Immunohistochemical stains included keratins 7 and 20, estrogen and progesterone receptors, CDX2, villin, CEA, WT-1, TTF-1, mammoglobin, GCDF-15, and CD31. Clinical data were considered as gold standard, and after clinicopathologic evaluation, the tissue of origin was found in 29 cases. The Tissue of Origin-Frozen test correctly identified the ovary as site of origin in 7 of 7 peritoneal carcinomatosis cases, whereas immunohistochemical stains only allowed appropriate recognition in 5. In addition, the Tissue of Origin-Frozen test identified correctly the site of origin in 18 of the 22 metastatic tumors to the ovary with known origin. In the remaining 4 tumors, the correct origin was the second option in 2 cases and was not determined in the other 2. Immunohistochemistry correctly identified the site of origin in 17 of these 22 ovarian metastases. A combination of Tissue of Origin-Frozen and immunohistochemistry correctly identified the site of origin in 19 of 22 ovarian metastases of known origin. Although conventional pathologic examination and immunohistochemistry are commonly used for assessing the tumor site of origin, Tissue of Origin testing can be useful in difficult cases.



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Advances in Understanding Anesthesia



http://www.newswise.com/articles/view/593206/?sc=rsla&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+NewswiseLatestNews+%28Newswise%3A+Latest+News%29&utm_content=Google+Reader


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ScienceDirect.com - Journal of the American College of Radiology - Geographic and Sociodemographic Disparities in PET Use by Medicare Beneficiaries With Cancer



Original article

Geographic and Sociodemographic Disparities in PET Use by Medicare Beneficiaries With Cancer




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