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Sunday, June 21, 2009

Evidence and Values: Requirements for Public Reimbursement of Drugs for Rare Diseases - a Case Study in Oncology



Conclusion:

There should be a greater commitment by reimbursement agencies to a fair and transparent decisionmaking process with appropriate community input. Criteria should be developed to validate surrogate
markers for rare diseases. It should also be acknowledged that the traditional measures of benefit in
economic studies do not incorporate all elements of social value.
The need should be recognized to balance equity with an efficient use of resources.

Measuring Response with FDG-PET: Methodological Aspects



Note reference to PET/CT; 1 small mention of ovarian cancer

‘CRAP’ Paper Accepted For Publication / Science News



“This is a kind of betrayal”: a qualitative study of disability after breast cancer



abstract & commentary: Postmenopausal Hormone Treatment, June 17, 2009



Age-dependent penetrance of different germline mutations in the BRCA1 gene (breast/ovarian...)



Low drug resistance to both platinum and taxane chemotherapy on an in-vitro drug resistance assay predicts improved survival in OC, PP, FT



Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial OC: GOG



"CONCLUSIONS: c-MYC amplification and polysomy 8 have limited predictive or prognostic value in suboptimally-resected, advanced stage EOC treated with platinum-based combination chemotherapy."