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Monday, May 25, 2015

Effectiveness of the RMI & ROMA Algorithm - Cohort of Women With OC: Does Histotype and Stage Matter?


Objective: To examine the performance of the Risk of Malignancy Index (RMI) and Risk of Ovarian Malignancy Algorithm (ROMA) by histologic subtype and stage of disease in a cohort of women with ovarian cancer.

Methods: All patients with confirmed ovarian cancer at the Princess Margaret Hospital between February 2011 and January 2013 were eligible for study inclusion. Preoperative cancer antigen 125, human epididymis protein 4, and ultrasound findings were reviewed, and the sensitivity and false-negative rates of the RMI and ROMA were determined by stage of disease and tumor histology.

Results: A total of 131 patients with ovarian cancer were identified. High-grade serous (HGS) histology was most frequently associated with stage III/IV disease (n = 46 [72% of stage III/IV]) vs stage I (n = 5 [11% of stage I]; P < 0.0001). Clear cell (CC) and endometrioid (EC) histology presented most commonly with stage I disease (n = 9 [20%] and n = 13 [29% of stage I cases], respectively). Median cancer antigen 125 and human epididymis protein 4 values were significantly higher for HGS than for EC or CC histology. Risk of Malignancy Index II demonstrated the highest sensitivity of the 3 RMI algorithms. All RMIs and ROMA were significantly more sensitive in predicting malignancy in patients with HGS than EC or CC histology. Risk of Malignancy Index II (n = 38) and ROMA (n = 35) exhibited sensitivities of 68% and 54% and false-negative rates of 32% and 46%, respectively, for patients with stage I disease vs sensitivities of 94% and 93% and false-negative rates of 6% and 7% for patients with stage III/IV disease.

Conclusion: Both RMI and ROMA performed well for the detection of advanced ovarian cancer and HGS histology. These triaging algorithms do not perform well in patients with stage I disease where EC and CC histologies predominate. Clinicians should be cautious using RMI or ROMA scoring tools to triage isolated adnexal masses because many patients with stage I malignancies would be missed.

Index: Intl Journal of Gynecological Cancer June 2015

Current Issue


Purchase Access

Table of Contents Outline

Letter to the Editor

Basic Science

Outcomes of Ovarian Germ Cell Tumors: Ten Years of Experience at the Brazilian National Cancer Institute

A Series of Malignant Ovarian Cancers Arising From Within a Mature Cystic Teratoma: A Single Institution Experience

Does a Standardized Preoperative Algorithm of Clinical Data Improve Outcomes in Patients With Ovarian Cancer? A Quality Improvement Project

Percutaneous Cryoablation of Ovarian Cancer Metastasis to the Liver: Initial Experience in 13 Patients

Effectiveness of the Risk of Malignancy Index and the Risk of Ovarian Malignancy Algorithm in a Cohort of Women With Ovarian Cancer: Does Histotype and Stage Matter?

Prognostic Factors for Ovarian Epithelial Cancer in the Elderly: A Case-Control Study

The Impact of Percent Reduction in CA-125 Levels on Prediction of the Extent of Interval Cytoreduction and Outcome in Patients With Advanced-Stage Cancer of Müllerian Origin...

Outcome of Patients With Advanced-Stage Borderline Ovarian Tumors After a First Peritoneal Noninvasive Recurrence: Impact on Further Management

Uterine Cancer

Magnetic Resonance Imaging in the Assessment of High-Risk Features of Endometrial Carcinoma: A Meta-Analysis

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Role of SUVmax and GLUT-1 Expression in Determining Tumor Aggressiveness in Patients With Clinical Stage I Endometrioid Endometrial Cancer

Incidence and Survival of Gynecologic Sarcomas in England

The Use of Transvaginal Ultrasound in Type II Endometrial Cancer

Strong Correlation Between Molecular Changes in Endometrial Carcinomas and Concomitant Hyperplasia

Isolated Port-Site Metastases After Minimally Invasive Hysterectomy for Endometrial Cancer: Outcomes of Patients Treated With Radiotherapy

Incidence of Nodal Metastasis and Isolated Aortic Metastases in Patients With Surgically Staged Endometrioid Endometrial Cancer

Stage I Granulosa Cell Tumors: A management conundrum? Results of long-term follow up. - PubMed - NCBI


Optimal management of women with early stage GCT presents a management conundrum - they have excellent prognosis but a third will relapse. Advances uncovering the molecular characteristics of GCTs have not been matched by improvements in our understanding and treatment.


Stage I GCT patients referred to Auckland City Hospital (1955-2012) and Princess Margaret Cancer Centre (1992-2012) were identified. Baseline characteristics, histopathology and outcomes were recorded retrospectively.


One hundred and sixty stage I GCT patients were identified with median age of 49 years. Median follow-up was 7.0 years (range 0.1-44.2 years). Fifty-one patients (32%) relapsed with a median time to relapse (TTR) of 12.0 years (1.3-17.7 years) - 20 initial relapses occurred 10 years post-diagnosis. Higher relapse rates (43% vs. 24% p=0.02) and shorter TTR (10.2 vs. 16.2 years p=0.007) were seen with stage Ic versus stage Ia disease. Cyst rupture was associated with increased relapse (p=0.03). Surgery was the main therapeutic modality at relapse. Eighty six percent of patients received non-surgical management at least once post-relapse. Clinical benefit rate was 43% with chemotherapy, 61% with hormonal therapy and 86% with radiation. Five- and 10-year overall survival (OS) were 98.5 and 91.6%, respectively. Median OS was similar in patients with (24.3 years) and without relapse (22.3 years).


Surgery remains fundamental at diagnosis and relapse. Caution should be exercised in recommending adjuvant chemotherapy at initial diagnosis given OS was greater than 20 years even with relapse. Hormonal therapy at relapse appears encouraging but needs further assessment. Novel treatment strategies need exploration with international collaboration essential for this.

Does ovarian stimulation for IVF increase gynaecological cancer risk? A systematic review and meta-analysis


 The aim of this study was to evaluate whether ovarian stimulation for IVF increases the risk of gynaecological cancer, including ovarian, endometrial, cervical and breast cancers, as an independent risk factor. A systematic review and meta-analysis was conducted. Clinical trials that examined the association between ovarian stimulation for IVF and gynaecologic cancers were included. The outcomes of interest were incidence rate of gynaecologic cancers. Twelve cohort studies with 178,396 women exposed to IVF were included; 10 studies were used to analyse ovarian (167,640 women) and breast (151,702 women) cancers, and six studies were identified in the analysis of endometrial (116,672 women) and cervical cancer (114,799 women). Among these studies, 175 ovarian, 48 endometrial, 502 cervical and 866 cases of breast cancer were reported. The meta-analysis found no significant association between ovarian stimulation for IVF and increased ovarian, endometrial, cervical and breast cancer risk (odds ratio [OR] 1.06, 95% confidence interval [CI] 0.85 to 1.32; OR 0.97, 95% CI 0.58 to 1.63; OR 0.43, 95% CI 0.30 to 0.60; OR 0.69, 95% CI 0.63 to 0.76, respectively). Ovarian stimulation for IVF, therefore, does not increase the gynaecologic cancer risk, whether hormone-dependent endometrial and breast cancer or non-hormone-dependent ovarian and cervical cancer.

Sunday, May 24, 2015

Index: Vol 137 issue 3 June 2015 Gynecologic Oncology (journal) - not open access

Gynecologic OncologyGynecologic Oncology
Volume 137, Issue 3 ,  Pages 363-600, June 2015

Editorial Board   

The ideal adjuvant treatment in node positive vulvar cancer is (fill in your best guess here)   
Pages 363-364
Mitchell Kamrava

  Original Research Reports

  Lead Article
Impact of adjuvant chemotherapy with radiation for node-positive vulvar cancer: A National Cancer Data Base (NCDB) analysis   Original Research Article
Pages 365-372
Beant S. Gill, Mark E. Bernard, Jeff F. Lin, Goundappa K. Balasubramani, Malolan S. Rajagopalan, Paniti Sukumvanich, Thomas C. Krivak, Alexander B. Olawaiye, Joseph L. Kelley, Sushil Beriwal

  Vulvar Cancer
Prognostic role of inguinal lymphadenectomy in vulvar squamous carcinoma: younger and older patients should be equally treated. A prospective study and literature review   Original Research Article
Pages 373-379
Pierluigi Benedetti Panici, Federica Tomao, Lavinia Domenici, Andrea Giannini, Diana Giannarelli, Innocenza Palaia, Violante Di Donato, Angela Musella, Roberto Angioli, Ludovico Muzii
Vulvar and vaginal reconstruction using the “angel wing” perforator-based island flap   Original Research Article
Pages 380-385
Sang Wha Kim, Won Moo Lee, Jeong Tae Kim, Youn Hwan Kim

  Ovarian Cancer
A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation — An NRG Oncology/Gynecologic Oncology Group study   Original Research Article
Pages 386-391
Robert L. Coleman, Michael W. Sill, Katherine Bell-McGuinn, Carol Aghajanian, Heidi J. Gray, Krishnansu S. Tewari, Steven C. Rubin, Thomas J. Rutherford, John K. Chan, Alice Chen, Elizabeth M. Swisher
Weekly ixabepilone with or without biweekly bevacizumab in the treatment of recurrent or persistent uterine and ovarian/primary peritoneal/fallopian tube cancers: A retrospective review   Original Research Article
Pages 392-400
Dana M. Roque, Elena S. Ratner, Dan-Arin Silasi, Masoud Azodi, Thomas J. Rutherford, Peter E. Schwartz, Wendelin K. Nelson, Alessandro D. Santin
Delay in chemotherapy administration impacts survival in elderly patients with epithelial ovarian cancer   Original Research Article
Pages 401-405
Naima Joseph, Rachel M. Clark, Don S. Dizon, Malinda S. Lee, Annekathryn Goodman, David Boruta, John O. Schorge, Marcela G. del Carmen, Whitfield B. Growdon
Predictors of postoperative morbidity after cytoreduction for advanced ovarian cancer: Analysis and management of complications in upper abdominal surgery   Original Research Article
Pages 406-411
Pierluigi Benedetti Panici, Violante Di Donato, Margherita Fischetti, Assunta Casorelli, Giorgia Perniola, Angela Musella, Claudia Marchetti, Innocenza Palaia, Pasquale Berloco, Ludovico Muzii
The clinical value of surgeons' efforts of preventing intraoperative tumor rupture in stage I clear cell carcinoma of the ovary: A Korean multicenter study   Original Research Article
Pages 412-417
Dong Hoon Suh, Jeong-Yeol Park, Jung-Yun Lee, Byoung-Gie Kim, Myong Cheol Lim, Jae-Weon Kim, Duk-Soo Bae, Sang-Yoon Park, Joo-Hyun Nam, Kidong Kim, Jae Hong No, Yong-Beom Kim

  Ovarian Germ Cell Tumors
Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors   Original Research Article
Pages 418-422
Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam

  Cancer Genetics and Biomarkers
The sooner the better: Genetic testing following ovarian cancer diagnosis   Original Research Article
Pages 423-429
E. Fox, J. McCuaig, R. Demsky, C. Shuman, D. Chitayat, M. Maganti, J. Murphy, B. Rosen, S. Ferguson, S. Randall Armel
Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms: Clinical correlates   Original Research Article
Pages 430-435
John B. Liao, Yuen Yee Yip, Elizabeth M. Swisher, Kathy Agnew, Karl Erik Hellstrom, Ingegerd Hellstrom

  Uterine Cancer
Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer   Original Research Article
Pages 436-442
J. How, W.H. Gotlieb, J.Z. Press, J. Abitbol, M. Pelmus, A. Ferenczy, S. Probst, R. Gotlieb, S. Brin, S. Lau

Graphical abstract

Sentinel node mapping with indocyanine green and endoscopic near-infrared fluorescence imaging in endometrial cancer. A pilot study and review of the literature   Original Research Article
Pages 443-447
Marie Plante, Omar Touhami, Xuan-Bich Trinh, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Jean Gregoire
Circadian actigraphic rest–activity rhythms following surgery for endometrial cancer: A prospective, longitudinal study   Original Research Article
Pages 448-455
Meredith E. Rumble, Stephen L. Rose, Kaitlin Hanley White, A. Holliston Moore, Philip Gehrman, Ruth M. Benca, Erin S. Costanzo
Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center   Original Research Article
Pages 456-461
M.R. Davis, B.E. Howitt, B.J. Quade, C.P. Crum, N.S. Horowitz, D.P. Goldstein, R.S. Berkowitz

  Cervical Cancer
A randomized trial comparing concurrent chemoradiotherapy with single-agent cisplatin versus cisplatin plus gemcitabine in patients with advanced cervical cancer: An Asian Gynecologic Oncology Group study   Original Research Article
Pages 462-467
Chun-Chieh Wang, Hung-Hsueh Chou, Lan-Yan Yang, Hao Lin, Wen-Shiung Liou, Chih-Wen Tseng, Feng-Yuan Liu, Jui-Der Liou, Kuan-Gen Huang, Huei-Jean Huang, Eng-Yen Huang, Chien-Hsun Chen, Ting-Chang Chang, Chee-Jen Chang, Ji-Hong Hong, Chyong-Huey Lai
Primary surgery versus primary radiation therapy for FIGO stages I–II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study   Original Research Article
Pages 468-473
Tze-Chien Chen, Huei-Jean Huang, Tao-Yeuan Wang, Lan-Yan Yang, Chi-Hau Chen, Ya-Min Cheng, Wen-Hsiung Liou, Shih-Tien Hsu, Kuo-Chang Wen, Yu-Che Ou, Yao-Ching Hung, Hung-Cheng Lai, Chih-Ming Ho, Ting-Chang Chang
The prognostic significance of histologic type in early stage cervical cancer – A multi-institutional study   Original Research Article
Pages 474-478
Ira Winer, Isabel Alvarado-Cabrero, Oudai Hassan, Quratulain F. Ahmed, Baraa Alosh, Sudeshna Bandyopadhyay, Sumi Thomas, Samet Albayrak, Shobhana Talukdar, Zaid Al-Wahab, Mohamed A. Elshaikh, Adnan Munkarah, Robert Morris, Rouba Ali-Fehmi

  Health Services Research
Costs of treatment for elderly women with advanced ovarian cancer in a Medicare population   Original Research Article
Pages 479-484
G.K. Forde, J. Chang, A. Ziogas, K. Tewari, R.E. Bristow
Patterns and utility of routine surveillance in high grade endometrial cancer   Original Research Article
Pages 485-489
Jessica Hunn, Meaghan E. Tenney, Ana I. Tergas, Erin A. Bishop, Kathleen Moore, William Watkin, Carolyn Kirschner, Jean Hurteau, Gustavo C. Rodriguez, Ernst Lengyel, Nita K. Lee, S. Diane Yamada
A Markov model to evaluate cost-effectiveness of antiangiogenesis therapy using bevacizumab in advanced cervical cancer   Original Research Article
Pages 490-496
Lindsey E. Minion, Jiaru Bai, Bradley J. Monk, L. Robin Keller, Eskander N. Ramez, Gareth K. Forde, John K. Chan, Krishnansu S. Tewari
Geographic disparities amongst patients with gynecologic malignancies at an urban NCI-designated cancer center   Original Research Article
Pages 497-502
Sarah M. Temkin, Saroj A. Fleming, Selma Amrane, Nicholas Schluterman, Mishka Terplan
Selective cardiac surveillance in patients with gynecologic cancer undergoing treatment with pegylated liposomal doxorubicin (PLD)   Original Research Article
Pages 503-507
C.L. Kushnir, A.M. Angarita, L.J. Havrilesky, S. Thompson, D. Spahlinger, A.K. Sinno, E.J. Tanner, A.A. Secord, K.L. Roche, R.L. Stone, A.N. Fader

  Quality of Life
Feasibility of a lifestyle intervention for overweight/obese endometrial and breast cancer survivors using an interactive mobile application   Original Research Article
Pages 508-515
Michele L. McCarroll, Shannon Armbruster, Rachael J. Pohle-Krauza, Amy M. Lyzen, Sarah Min, David W. Nash, G. Dante Roulette, Stephen J. Andrews, Vivian E. von Gruenigen
Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial   Original Research Article
Pages 516-522
Jannah Baker, Monika Janda, Nick Graves, Judy Bauer, Merrilyn Banks, Andrea Garrett, Naven Chetty, Alex J. Crandon, Russell Land, Marcelo Nascimento, James L. Nicklin, Lewis C. Perrin, Andreas Obermair
Post-operative enteral immunonutrition for gynecologic oncology patients undergoing laparotomy decreases wound complications   Original Research Article
Pages 523-528
J.S. Chapman, E. Roddy, G. Westhoff, E. Simons, R. Brooks, S. Ueda, L. Chen

  Translational Science
Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma   Original Research Article
Pages 529-537
Per-Henrik D. Edqvist, Jutta Huvila, Bjorn Forsstrom, Lauri Talve, Olli Carpen, Helga B. Salvesen, Camilla Krakstad, Seija Grenman, Henrik Johannesson, Oscar Ljungqvist, Mathias Uhlen, Fredrik Ponten, Annika Auranen
The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition   Original Research Article
Pages 538-545
Tomohiko Fukuda, Katsutoshi Oda, Osamu Wada-Hiraike, Kenbun Sone, Kanako Inaba, Yuji Ikeda, Aki Miyasaka, Tomoko Kashiyama, Michihiro Tanikawa, Takahide Arimoto, Hiroyuki Kuramoto, Tetsu Yano, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
PRSS3 expression is associated with tumor progression and poor prognosis in epithelial ovarian cancer   Original Research Article
Pages 546-552
Ruiqiong Ma, Xue Ye, Hongyan Cheng, Yu Ma, Heng Cui, Xiaohong Chang

Predictors of optimal cytoreduction in patients with newly diagnosed advanced-stage epithelial ovarian cancer: Time to incorporate laparoscopic assessment into the standard of care   Review Article
Pages 553-558
Natalia Rodriguez Gomez-Hidalgo, Bertha Alejandra Martinez-Cannon, Alpa M. Nick, Karen H. Lu, Anil K. Sood, Robert L. Coleman, Pedro T. Ramirez
Epithelial ovarian cancer and recreational physical activity: A review of the epidemiological literature and implications for exercise prescription   Review Article
Pages 559-573
Rikki A. Cannioto, Kirsten B. Moysich
Immediate radical trachelectomy versus neoadjuvant chemotherapy followed by conservative surgery for patients with stage IB1 cervical cancer with tumors 2 cm or larger: A literature review and analysis of oncological and obstetrical outcomes   Review Article
Pages 574-580
Rene Pareja, Gabriel J. Rendon, Monica Vasquez, Lina Echeverri, Carlos Millan Sanz-Lomana, Pedro T. Ramirez
Uterine carcinosarcoma: A review of the literature   Review Article
Pages 581-588
Leigh A. Cantrell, Stephanie V. Blank, Linda R. Duska

  Surgical Film
Controlled removal of a large uterus within a bowel bag and morcellation in the bowel bag from the vagina   
Pages 589-590
Diana English, Gulden Menderes, Masoud Azodi

  Winter Meeting Abstracts
Abstract 1: Gynecologic oncologists as benign gynecologic surgeons   
Pages 591
W. Baker, E. Chang, E. Pelkofski, L. Duska
Abstract 2: Prognostic significance of POLE exonuclease domain mutations in high grade endometrioid endometrial cancer on survival and recurrence   
Pages 591-592
C.C. Billingsley, E.M. Hade, D.E. Cohn, D.G. Mutch, P.J. Goodfellow
Abstract 3: Inhibition of STAT3 in ovarian clear cell carcinoma results in decreased cell proliferation and induction of apoptosis   
Pages 592
K. Bixel, U. Saini, J. Fowler, S. Rajendiran, R. Wanner, K. Hideg, D.E. Cohn, S. Karuppaiyah
Abstract 4: Differential gene expression associated with Lynch syndrome in patients less than and over 60 years of age with endometrial adenocarcinoma   
Pages 592
O. Dziadek, B. Shoup, K. Williams
Abstract 5: Evaluation of universal immunohistochemistry screening for diagnosing Lynch syndrome in endometrial cancer patients at a tertiary care center   
Pages 592-593
E.G. Hartnett, A. Stuckey, C. McCourt
Abstract 6: Proposed algorithm for the management of age 21 and older undergoing primary cervical cancer screening using primary HPV testing with cytology or colposcopy triage: A decision analysis   
Pages 593
N. Joseph, R. Pilliod, R. Clark, A. Goodman, W. Growdon
Abstract 7: Impact of age on 30-day mortality and morbidity in patients undergoing surgery for endometrial cancer   
Pages 593
K. Maurer, H. Mahdi
Abstract 8: The effects of obesity on oncologic outcomes in patients with ovarian cancer   
Pages 593-594
M. McDonald, A. O’Shea, M. Goodheart, D. Bender, J. Gonzalez Bosquet, A. Button, J. Stephan
Abstract 9: Low utility of cytology screening for other lower genital tract neoplasia (LGTN) following chemoradiation (CRT) for cervical cancer (CxCA)   
Pages 594
S. Park, C. Holschneider, M. Amneus
Abstract 10: Does routine post-treatment PET/CT add value to the care of women with locally advanced cervical cancer?   
Pages 594-595
N.T. Phippen, L.J. Havrilesky, J.C. Barnett, C.A. Hamilton, M. Stany, W.J. Lowery
Abstract 11: Morcellation and the incidence of occult malignancy: a dual-institution review   
Pages 595
T. Picerno, M. Wasson, M. Hoffman, M.E. Borowsky
Abstract 12: Perioperative blood transfusion in gynecologic surgery   
Pages 595
L. Prescott, T. Aloia, A. Brown, J. Taylor, C. Sun, C. Levenback, K. Schmeler, D. Bodurka
Abstract 13: Trends in treatment of uterine serous cancer in the medicare population   
Pages 595-596
JA Rauh-Hain, S. Connor, J.B. Clemmer, R.M. Clark, T. Hall, W.B. Growdon, A.K. Goodman, D. Boruta, J.O. Schorge, M.G. del Carmen
Abstract 14: Glutamine supports ovarian cancer cell proliferation through modulation of the mTOR/S6 pathway   
Pages 596
D.R. Roque, L. Yuan, W.Z. Wysham, C. Zhou, V. Bae-Jump
Abstract 15: Cancer-related fatigue in gynecologic oncology patients undergoing chemotherapy   
Pages 596
K. Shields, C. Craig, L. Baxter, L. Renda, J. Pipe, B. Monk, D. Chase
Abstract 16: Multimodal pain control is associated with reduced hospital stay following open abdominal hysterectomy   
Pages 596
M. Ulm, J. Santoso, B. Jennings, J. Wan
Abstract 17: Knowledge of risk factors associated with endometrial cancer in a general gynecologic population   
Pages 597
C. Washington, W. Ronner, P. Neff, A. Haggerty, E. Ko
Abstract 18: Overa: a prediction tool using serum calcium to discriminate malignant from benign pelvic masses   
Pages 597
S.S. Winkler, M.G. Kelly, S.S. Lentz, S.H. Berliner, M.F. Swain, H.G. Skinner, G.G. Schwartz
Evaluation of three predictive models assessing debulkability of patients with advanced ovarian, fallopian tube, or primary peritoneal cancer   
Pages 597-598
C. Stashwick, L. Cory, M. Kelly
Making the case for salpingectomy as the elective sterilization procedure: A decision analysis   
Pages 598
S. Dilley, A. Allen, C. Lessard-Anderson, J. Bakkum-Gamez, Koenraad De Geest, A.B. Caughey, M.I. Rodriguez
Effect of preoperative chemotherapy on postoperative morbidity and mortality in patients undergoing surgery for ovarian cancer   
Pages 598-599
D. Doo, M. Guy, K. Behbakht, S. Davidson, J. Sheeder, S. Guntupalli
Lymphocyte nadir and reconstitution during chemotherapy predicts survival in ovarian cancer patients   
Pages 599
R. Brightwell, K. Eng, S. Lele, P. Frederick, S. Akers, A. Odunsi
Impact of age on 30-day mortality and morbidity in patients undergoing surgery for ovarian cancer   
Pages 599
A. Wiechert, P. Rose, H. Mahdi

Erratum to “Should ovaries be removed or not in (early-stage) adenocarcinoma of the uterine cervix: A review” [Gynecol. Oncol. 136 (2015) 384–388]   
Pages 600
Omar Touhami, Marie Plante