- •Malignant transformation of extra-ovarian endometriosis is rare
- •Histology and immunohistochemistry support mullerian origin of this malignancy
- •Consideration can be given to extrapolating treatment from gynecologic literature
Case Report.A 44-year-old para 0, with a history of urge urinary incontinence and recurrent urinary tract infections, presented with urinary frequency, incontinence, and hematuria. In 2008, she was diagnosed with urge incontinence and treated with tolterodine with improvement in symptoms. Multiple urinalyses at that time were positive for blood. The patient was lost to follow up until 2015, when she re-presented with recurrent symptoms. A urinalysis revealed many red blood cells and multiple urine cultures were negative.....The immunoprofile itself could not distinguish primary bladder clear cell adenocarcinoma from metastatic clear cell adenocarcinoma from the gynecologic tract.
3.1.EpidemiologyUrothelial carcinomas (UCs) are the fifth most common tumours . They can be located in the lower (bladder and urethra) or upper (pyelocaliceal cavities and ureter) urinary tract. Bladder tumours account for 90-95% of UCs and are the most common malignancy of the urinary tract . In contrast, UTUCs are uncommon and account for only 5-10% of UCs [4,6]. Pyelocaliceal tumours are about twice as common as ureteral tumours. In 17% of cases, concurrent bladder cancer is present . Recurrence in the bladder occurs in 22-47% of UTUC patients , compared with 2-6% in the contralateral upper tract [9,10].Approximately 60% of UTUCs are invasive at diagnosis compared with 15-25% of bladder tumours [11,12]. UTUCs have a peak incidence in people aged 70-90 years and are three times more common in men [13,14].Familial/hereditary UTUCs are linked to (Lynch syndrome) hereditary non-polyposis colorectal carcinoma (HNPCC) , which can be screened for during interview (Figure 3.1) . Patients should undergo DNA sequencing to identify hereditary cancers misclassified as sporadic if they fulfil the criteria for HNPCC [15,17].
The (UK) study was published online September 15 in Pain.
The undertreatment of cancer pain is also a problem in the United States, said Judith A. Paice, PhD, RN, research professor in medicine-hematology/oncology at Northwestern University in Chicago, Illinois. Dr Paice is an expert who was not involved in the current study.Comments
"The problem in the United States may be worsening through the unintentional consequences associated with measures to limit the opioid abuse epidemic," Dr Paice told Medscape Medical News.
The decision to withdraw the MAA (Marketing Authorisation Application) was based on outstanding health authority questions that remain at this late stage of the review process. The MAA for cediranib was supported by data from ICON6, a Phase III trial led by the Medical Research Council (MRC) Clinical Trials Unit at UCL. AstraZeneca has not made additional regulatory submissions for cediranib in this indication in any other markets. AstraZeneca is committed to enhancing treatment options for patients with ovarian cancer, including developing chemotherapy-free alternatives to help delay or avoid the use of platinum-based chemotherapies.
Goates and colleagues drew their data from two large-scale national health care surveys, National Health and Nutrition Examination Survey, or Nhanes, and National Health Interview Survey over 6 years. The researchers looked specifically at variables related to nutrition among people with 8 chronic diseases: stroke, chronic obstructive pulmonary disease or COPD, coronary heart failure, breast cancer, dementia, musculoskeletal disorders, depression, and colorectal cancer.
The researchers indicate many patients with these conditions arrive at the hospital with malnutrition, even if obese, or become malnourished at the hospital, which can increase the risk of complications or delay recovery.
Some hospitals perform one or two brain cancer surgeries; others do hundreds. Small volumes can mean greater risk of poor patient outcomes. See the numbers for 11 cancers at hospitals across California.