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Monday, November 19, 2012

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells



Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells

Highlights

► Navitoclax and other BH3 mimetics have previously shown synergy with chemotherapeutic agents
► Where antagonism between carboplatin and/or paclitaxel was observed, this was reduced by the inclusion of navitoclax.
► Navitoclax improves the activity of carboplatin and/or paclitaxel in Igrov-1 spheroids.

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