A Young Woman With Bilateral Breast Cancer: Identifying a Genetic Cause and Implications for Management (BRCA1/2; Li-Fraumeni syndrome....)

Blogger's Note: of interest to those who may have had negative genetic testing results but with family histories of differing cancers; ovarian cancer is also a risk factor for LFS but potentially underreported in this syndrome

open access

"... Women with LFS have a greater than 90% lifetime risk of cancer,⁹ and most commonly develop sarcomas (bone and soft tissue), premenopausal breast cancer, acute leukemia, brain tumors, adrenocortical carcinoma, choroid plexus carcinoma, colon and pancreatic cancer, or melanoma.^7,10,11.....