Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer

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".......Although the molecular mechanisms linking TUBGCP4 or NAT10 with Stem-A growth remains to be elucidated, susceptibility to vincristine and vinorelbine underscores the importance of tubulin polymerization in Stem-A cells. Both drugs are well-established chemotherapeutic agents that block cell proliferation by inhibiting microtubule assembly through its interaction with tubulin heterodimers (Lobert et al, 1996); however, they are not standard chemotherapeutic reagents for the treatment of EOC, unlike paclitaxel (Armstrong et al, 2006; McGuire et al, 1996). The molecules implicated in the tubulin polymerization pathway may provide us with a potential platform to more effectively target Stem-A ovarian cancer. As such, the survival of patients with ovarian cancer could be improved by the stratification and targeting strategy described in this study."