abstract
The
objective of this study was to review the accuracy of indices combining
several diagnostic variables, in comparison to other models, sonography
alone, and biomarker assays, for predicting benign or malignant ovarian
lesions. Different single modalities were reviewed. The most useful
complex models were International Ovarian Tumor Analysis (IOTA)
sonographic logistic regression model 2 (area under the curve, 0.949),
risk of malignancy index-cancer antigen 125-human epididymis protein 4
(0.950), risk of malignancy algorithm (0.953), pelvic mass score
(0.960), non-IOTA logistic regression model (0.970), and histoscanning
score logistic regression model (0.970).
None of the indices was
superior to an expert subjective sonographic assessment (0.968). For
women with adnexal tumors, indices with high accuracy are available that
are applicable in clinical practice and
comparable to an expert
subjective sonographic assessment for discriminating benign from
malignant masses.
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