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Blog Archives: Nov 2004 - present
Special items: Ovarian Cancer and Us blog best viewed in Firefox
abstract
Radical nephroureterectomy with en bloc bladder cuff excision
and regional lymphadenectomy is the gold standard for the management of
high-grade and high-risk upper tract urothelial carcinomas (UTUC). There
are few prospective randomized controlled studies in this uncommon and
often aggressive disease to support level-1 management guidelines.
However, recent developments in imaging, minimally invasive techniques,
lymphatic dissemination, and bladder cancer prevention raise the hope
for improved risk stratification and treatments without compromising,
and hopefully improving, oncological outcomes. Multi-modality approaches
in terms of neoadjuvant, adjuvant topical and systemic chemotherapeutic
regimens are promising, with 2 prospective trials either open or in
development.
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