|
|
|
|
|
|
|
|
Novel Precision Medicine Trial Designs | Oncology | JAMA Oncology | The JAMA Network
What Is Precision Medicine in Cancer, and Why Do We Need New Trial Designs?
Precision medicine in cancer care leads us to transition
from a “one size fits all” approach of categorizing cancers by the body
organ where they began (eg, breast, lung, colon) to a focus instead on
specific identified mutations that may drive a cancer. One advantage of
the old model of treating broad populations with the same approach was
that it was possible to conduct studies that included many patients who,
we thought, shared the same disease. With the greater resolution of
precision medicine looking for particular mutations, we now must split
those populations into much smaller subgroups. In some cases, these
subgroups may be just a very small percentage of the overall population
of patients with a given cancer, creating challenges in how to study the
best treatments for them.
Two new and very different trial designs for molecular targets in cancer care are umbrella trials and basket trials......
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.