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Genital use of talc and risk of ovarian cancer: a meta-analysis
(abstract) January 11, 2017
Some
epidemiological studies suggest an association between genital use of
talc powders and increased risk of ovarian cancer, but the evidence is
not consistent. We performed a meta-analysis of epidemiological studies
to formally evaluate this suspected association. A systematic search was
conducted in Medline, Embase, and Scopus, leading to the identification
of 24 case-control studies and three cohort studies, including 302 705
women with ovarian cancer. In the meta-analysis, we used a random-effect
model to calculate summary estimates of the association between genital
use of talc and occurrence of ovarian cancer. We assessed potential
sources of between-study heterogeneity and presence of publication bias.
The summary relative risk (RR) for ever use of genital talc and ovarian
cancer was 1.22 [95% confidence interval (CI): 1.13-1.30]. The RR for
case-control studies was 1.26 (95% CI: 1.17-1.35) and for cohort studies
was 1.02 (95% CI: 0.85-1.20, Pheterogeneity=0.007). Serous carcinoma
was the only histologic type for which an association was detected (RR:
1.24; 95% CI: 1.15-1.34). There was no trend in RR with either duration
or frequency of genital talc use. This meta-analysis resulted in a weak
but statistically significant association between genital use of talc
and ovarian cancer, which appears to be limited to serous carcinoma. The
heterogeneity of results by study design and the lack of a trend for
duration and frequency of use, however, detract from a causal
interpretation of this association.
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