|
|
|
|
|
|
|
|
|
|
Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer -- Hampel et al., 10.1200/JCO.2008.17.5950 -- Journal of Clinical Oncology
Conclusion:
One of every 35 patients with CRC has LS, and each has at least three relatives with LS; all of whom can benefit from increased cancer surveillance. For screening, IHC is almost equally sensitive as MSI, but IHC is more readily available and helps to direct gene testing. Limiting tumor analysis to patients who fulfill Bethesda criteria would fail to identify 28% (or one in four) cases of LS.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.