Polymorphic Variation of Genes in the Fibrinolytic System and the Risk of Ovarian Cancer

Polymorphic Variation of Genes in the Fibrinolytic System and the Risk of Ovarian Cancer

We failed to detect any significant association between fibrinolysis gene polymorphisms and the incidence of ovarian cancer in any histological subtype. If the fibrinolytic pathway is involved in ovarian cancer, the risk does not appear to be influenced by functional polymorphisms in the key genes. However, given the previous studies, which report a possible role for these enzymes in the initiation or progression of cancer, it may be that variation in the expression of the proteins in the fibrinolytic system remains relevant for ovarian carcinogenesis.