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See also Table 1:Occult Influences of the Clinical Trial Setting on the Generalizability of Results - Differences in the Patient Population
"As clinical trials increasingly become a global enterprise, issues of generalizability will increase in importance. It will be essential to ensure that the conduct of a trial and its subsequent reporting include attention to aspects that influence generalizability, so that determinations of whether observations and conclusions reached in one geographic setting, or within one type of health care system, are applicable to the policy makers and practitioners from other settings."
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