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"Among women, an increased rate of mortality was observed both for deficient concentrations and very high concentrations (>124nmol/L). Results suggest that caution should be exercised in using very high dose vitamin D supplementation in prevention trials that may result in high concentrations of vitamin D (>100nmol/L). Results suggest that caution should be exercised in using very high dose vitamin D supplementation in prevention trials that may result in high concentrations of vitamin D (>100nmol/L)."
If and when you have the time could you give a complete reference for this please, I tried to find it online but couldn't track it down.
ReplyDelete(I'm pretty sure vitamin D supplementation is a Pandora's box myself)
Thanks. If you click on the title it will take you directly to the Journal of Cancer Prevention Research and the abstract. It was the abstract presented at the AACR International Conference on Frontiers in Cancer Prevention Research-- Dec 6-9, 2009; Houston, TX. For more details, I would suggest either contacting the authors directly or via your oncologist. Hope this helps just a bit.
ReplyDeleteThanks,
ReplyDeletePolymorphisms in the Vitamin D Receptor and Risk of Ovarian Cancer in Four Studies.
"Among the prospective studies, the risk of ovarian cancer by plasma vitamin D levels did not clearly vary by any of the genotypes.
For example, among women with the Fok1 FF genotype, the OR comparing plasma 25-hydroxyvitamin D 32 ng/mL versus <32 ng/mL was 0.66 (95% CI, 0.34–1.28), and among women with the Ff or ff genotype the OR was 0.71 (95% CI, 0.43–1.18). Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis. [Cancer Res 2009;69(5):1885–91] "
Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: the French E3N cohort
Author's Response
On the roles of skin type and sun exposure in the risk of endometriosis and melanoma
"In a previous issue of the International Journal of Epidemiology,1 we described significant associations between some cutaneous phenotypic traits associated with melanoma risk and the risk of endometriosis among participants of the French E3N cohort. Dr Grant argues that these findings can be explained by a low vitamin D level in women with these phenotypic traits.
First, Dr Grant's statement that . . . "
Re Dr. William Grant and his vit. D or UVB / latitude hypothesis - 'Correlation between HLA-A2 gene frequency, latitude, ovarian and prostate cancer mortality rates
"the higher phenotype frequency of this allele found in Scandinavian countries decreases significa'ntly as one moves further south in Europe. Ovarian and prostate cancer mortality rates decrease as well as the demographic changes in HLA-A2."