Lynch Syndrome Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry Clinical Cancer Research Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, March 10, 2010

Lynch Syndrome Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry Clinical Cancer Research



Purpose: The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families.

(Breast cancers were reviewed by one pathologist. Tumor sections were stained for MLH1, PMS2, MSH2, and MSH6, and underwent microsatellite instability testing)  

Conclusions: MMR deficiency was identified in 51% of breast cancers arising in known mutation carriers. Breast cancer therefore may represent a valid tissue option for the detection of MMR deficiency in which spectrum tumors are lacking.

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