Medical News: SGO: Hint of Chemoprevention Potential for Lynch Syndrome (endometrial cancers) - in Meeting Coverage, SGO Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, March 16, 2010

Medical News: SGO: Hint of Chemoprevention Potential for Lynch Syndrome (endometrial cancers) - in Meeting Coverage, SGO



SAN FRANCISCO -- Oral contraceptives and medroxyprogesterone acetate (MPA, DepoProvera) may have potential as chemopreventive agents for endometrial cancer in women with Lynch syndrome, biomarker data from a small randomized trial suggest.
"Despite the favorable results, Lu noted that the trial required six years to complete, as investigators in the multicenter study had to screen 708 patients to identify 51 who met entry criteria and agreed to participate, including undergoing two endometrial biopsies three months apart."

read the full article & then my comments as below:

Without the benefit of the full paper, I found this article, in part to be quite confusing. In particular "screened women with diagnosed Lynch syndrome". While the first paragraph of the article reflects the focus on endometrial cancer in women with Lynch Syndrome, the paragraph as below, could also be interpreted to include ovarian cancer as well. So, were ovarian cancer patients with Lynch Syndrome included in this study? Chemoprevention in the form of oral contraceptives in the general ovarian cancer populations is well understood, whether or not this applies to ovarian cancer women with Lynch Syndrome may be yet to be determined.
Clarification, please?
Sandi Pniauskas

"To examine the chemopreventive effects of oral contraceptives and DepoProvera in women with Lynch syndrome, investigators conducted a randomized phase II clinical trial. They screened women with diagnosed Lynch syndrome and evaluated them with transvaginal ultrasound and endometrial biopsy."


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