April 2010: Genomics|Genetic Testing|EGAPP Recommendations|Lynch Syndrome

EGAPP Working Group Recommendation

Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives
Approximately 3% of people who develop colorectal cancer have an autosomal dominant inherited condition known as Lynch syndrome, sometimes referred to as Hereditary Nonpolyposis Colorectal Cancer or HNPCC. Individuals with this condition have a greatly increased chance to develop colorectal and other cancers, especially under age 50. Screening for Lynch syndrome in all patients with newly diagnosed colorectal cancer has been proposed to improve outcomes for patients and/or family members.
EGAPP Recommendation Statement: The EGAPP™ Working Group found sufficient evidence to recommend offering genetic testing for Lynch syndrome to individuals with newly diagnosed colorectal cancer (CRC) to reduce morbidity and mortality in relatives. We found insufficient evidence to recommend a specific genetic testing strategy among the several examined.

Note:  See website for access to the pdf files below (full free access):

• EGAPP Recommendation  (PDF 220KB) (Jan 2009)

• Evidence Report (May 2007)

• Supplementary Evidence Report (PDF 664KB) (Jan 2009)

• CDC Summary of Lynch Syndrome EGAPP Recommendation (Apr 2010)