Abstract (provisional)
Background
Angiogenesis appears to play an important role in ovarian cancer.
Vascular endothelial growth factor (VEGF) has recently been implicated
as a therapeutic target in ovarian cancer. The tissue inhibitor of
metalloproteinase 1 (TIMP-1) is involved in tissue invasion and
angiogenesis. The application of serum TIMP-1 and VEGF to monitor
primary therapy and predict clinical outcome of patients with ovarian
cancer is unclear.
Methods
Patients with epithelial ovarian cancer who presented for primary
surgery were included in this study. A total of 148 serum samples from
37 patients were analyzed. Samples were prospectively collected at 4
predefined time points: 1. before radical debulking surgery, 2. after
surgery and before platinum/taxane based chemotherapy, 3. during
chemotherapy, 4. after chemotherapy. Serum VEGF-165 and TIMP-1 as well
as CA-125 were quantified by ELISA or ECLIA and correlation with
response and long-term clinical outcome was analyzed.
Results
Serum levels of all markers changed substantially during first-line
therapy. High CA-125 (p=0.002), TIMP-1 (p=0.007) and VEGF-165 (p=0.02)
after chemotherapy were associated with reduced overall survival. In
addition, elevated CA-125 (p<0.001) and VEGF-165 (p=0.006) at this
time point predicted poor progression-free survival. TIMP-1 and VEGF-165
were closely correlated at all time-points during therapy.
Conclusions
TIMP-1 and VEGF serum levels changed significantly during first-line
therapy of ovarian cancer patients and predicted prognosis. These
findings support the role of angiogenesis in ovarian cancer progression
and the use of antiangiogenic therapy.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.