full free access: Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers -- Journal of Medical Genetics Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, June 30, 2010

full free access: Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers -- Journal of Medical Genetics



"Besides the high risk of developing colorectal carcinomas of 10–80%, Lynch syndrome family members are at increased risk of developing several extra-colonic cancers and tumours at a relatively young age: endometrial cancer, carcinomas of the ovary, small bowel and biliary tract cancer, sebaceous gland tumours and urothelial carcinomas (UC) of the upper urinary tract. The lifetime risk of upper urinary tract cancer in Lynch syndrome varies in different studies from 0.4–20%. Microsatellite instability (MSI) is present in these urothelial carcinomas of the upper urinary tract."

See Table 1

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