" Lifetime risk of developing gastric cancer was 8.0% in males vs 5.3% in
females and 4.8% and 9% for MLH1 and MSH2 carriers,
respectively."
Conclusions
Lynch syndrome mutation carriers have a substantial risk for gastric cancer, in particular patients with an
MLH1 or
MSH2 mutation. Family history for gastric cancer is a poor indicator for individual risk. Surveillance gastroscopy for
Lynch syndrome patients carrying an MLH1 or MSH2 mutation should therefore be considered.
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