2 Genes Have Possible Link to Deadly Ovarian Cancer - clear cell ovarian cancer

"Mutations in two genes may be associated with one of the most deadly types of ovarian cancer, U.S. researchers have found.

In the study, researchers at the Johns Hopkins Kimmel Cancer Center looked for mutations in 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients. The investigators found 268 mutations in 253 genes, with an average of 20 mutations per tumor......Further investigation revealed that two genes -- ARID1A and PPP2R1A -- were more commonly mutated than other genes..ARID1A is a gene whose product normally suppresses tumors. PPP2R1A is a gene that, when altered, helps turn normal cells into tumor cells. The genes had not previously been linked to ovarian cancer, the researchers explained in a news release from the Johns Hopkins Kimmel Cancer Center....."cont'd