GAPP KB|GAPP Finder - Mutation detection in BRCA 1/2 resources/info

Last data update: Sep-10-2010. (Total 204 GAPPs)
GAPP Finder
Data collected since October 2009	Home | About | Search Instructions | FAQs
Search Genomic Application Summary Evidence Translation Project for
Please Wait . . . . . . . . . . . . . . . . . . . . . . . . .

[Record Detail Page]

Genomic Application General Information

Disease/Disorder Breast cancer Test to be assessed Mutation detection in BRCA1 and BRCA2 genes (blood sample or oral rinse) Target Population Individuals who have breast or ovarian cancer in their family or a personal history of breast or ovarian cancer Intended Use To determine an individuals inherited risk for breast (and ovarian) cancer Sources/Links BRACNOW.com - Information for consumers Myriad.com - BRACAnalysis USPSTF - BRCA evidence review USPSTF - BRCA recommendation ABClocal.go.com - BVH offers test on genetic probability of breast cancer Key Indexed Terms Mammary Neoplasms [Disease] ovarian neoplasm [Disease] BRCA1 [Gene] BRCA2 [Gene] Application Type Risk prediction Status Commercially available Trade Name BRACAnalysis Company Myriad Genetics Notes USPSTF has conducted an evidence review Entered Date 08/20/2010 Last Updated Date 08/30/2010

Relevant Information

Evidence Summary from Evidence Aggregator

EGT : CYP2D6 testing to predict response to tamoxifen in women with breast cancer See detail EGAPP Recommendation : Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer? See detail Other Review : HER2 Testing to Manage Patients With Breast Cancer or Other Solid Tumors See detail EGAPP Review : Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes See detail Other Review : Genomic Tests for Ovarian Cancer Detection and Management See detail