Home : Nature Genetics re: BRCA 1/breast cancer/ polymorphisms (SNP's - international genome study)

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Genetics of breast cancer

Letter by Antonius Antoniou et al.

Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers with breast cancer and BRCA1 mutation carriers without breast cancer. They identify a locus at 19p13 associated with breast cancer risk in BRCA1 mutation carriers, and replication studies show that this locus associates with estrogen receptor-negative breast cancer in the general population.

Advance Online Publication

Genetics of ovarian cancer

Letter by Ellen Goode et al. Letter by Kelly Bolton et al.

Simon Gayther and colleagues report a genome wide association study for ovarian cancer. They identify two new susceptibility loci at 2q31 and 8q24. Separately, Paul Pharoah and colleagues report a genome-wide association study for survival time after diagnosis of epithelial ovarian cancer. They identify a locus at 19p13 associated with susceptibility to the serous subtype of epithelial ovarian cancer.