Making strides in ovarian cancer research « BC Cancer Foundation's Blog - re: clear cell ovarian cancer/endometriosis

"We were able to show that ARID1A mutated in close to 50 per cent of clear cell carcinomas of the ovary and in a slightly fewer number of the related endometrioid carcinomas.
When we studied in detail two cases where there was endometriosis attached to the tumour, we found that the mutation was present even before the cells in endometriosis looked like cancer cells. This suggests that ARID1A mutations are a very early event and likely critical to the transformation of a non-cancerous disease into cancer.
We are fully confident that this discovery marks the start of finding real treatments for clear cell carcinoma – but there is still a lot of work to do in the future...."