Methylation profiles of hereditary and sporadic ovarian cancer - Histopathology - abstract Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

Blog Archives: Nov 2004 - present

#ovariancancers



Special items: Ovarian Cancer and Us blog best viewed in Firefox

Search This Blog

Monday, September 06, 2010

Methylation profiles of hereditary and sporadic ovarian cancer - Histopathology - abstract



Conclusions: 

 CDH13, GSTP1 and RASSF1 are frequently methylated in both sporadic and BRCA1-associated ovarian cancers. Interestingly, methylation of BRCA1, while frequent in sporadic ovarian cancer, never occurred in the hereditary group. BRCA1-associated ovarian cancers mimic their sporadic counterparts in extent and pattern of promoter methylation of several common tumour suppressor genes. This finding could have implications for future chemotherapy regimens based on epigenetic changes

0 comments :

Post a Comment

Your comments?

Note: Only a member of this blog may post a comment.