The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients (study number 289 patients)

Note: MSH2/MSH6 are 2 of the Lynch Syndrome genes

Objectives

The genes associated with familial Endometrial Cancer (EC) are largely unknown. While EC is an integral part of Hereditary Non-Polyposis Colon Cancer, there is an ongoing debate if EC is indeed overrepresented in hereditary breast/ovarian cancer families.

Conclusions

Our data do not support screening for BRCA1/2 mutations in consecutive EC patients.