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Blog Archives: Nov 2004 - present
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OBJECTIVE: Tamoxifen,
a medication used in the treatment of breast cancer, often induces
menopausal symptoms. Certain medications and natural supplements taken
or prescribed to alleviate tamoxifen-induced hot flashes and depressive
states in women with breast cancer interact with tamoxifen. This paper
reviews potentially problematic interactions and offers treatment
recommendations.
CONCLUSIONS: Clinicians
should remain cautious about using strong inhibitors and/or inducers of
cytochrome 2D6 and 3A4 concomitantly with tamoxifen. Use of natural
menopausal supplements and diets rich in isoflavones should not be
encouraged in tamoxifen users until more data is available. There are
however safe treatments for hot flashes and depression in tamoxifen
users.
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