Correspondence: mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient With Peutz-Jeghers Syndrome

TO THE EDITOR:

"Recently, we successfully used everolimus to
achieve a partial remission in a patient with advanced pancreatic
cancer that was induced by Peutz-Jeghers syndrome (PJS). PJS has
been associated with an increased risk of GI, gynecologic, breast, and
pancreatic cancers. PJS is caused by a tumor-suppressor gene mutation
in the serine threonine kinase gene 11 (STK11, also known as
LKB1 gene), localized on chromosome 19p13.3.1,2 Up to 93% of
patients with PJS develop some form of cancer; 11% to 36% develop
pancreatic carcinoma.3,4......"