full free access (pdf): A phase I study with an expanded cohort to assess the feasibility of intraperitoneal carboplatin and intravenous paclitaxel in untreated ovarian, fallopian tube, and primary peritoneal carcinoma: A Gynecologic Oncology Group study

Research Highlights

► The MTD (maxium tolerated dose) of IP carboplatin with IV paclitaxel (175 mg/m²) was an AUC 8.
►IP carboplatin can be given with IV paclitaxel over multiple cycles at an AUC 6.
►Dose-limiting toxicities of IP carboplatin were thrombocytopenia and leukopenia.