full free access: Meta-analysis: Circulating vitamin D and ovarian cancer risk

OBJECTIVE: To review and summarize evidence from longitudinal studies on the association between circulating 25 hydroxyvitamin D (25(OH)D) and the risk of ovarian cancer (OC).


RESULTS: Overall, ten individual-level studies were included that reported on the association between circulating vitamin D levels and OC incidence..........

CONCLUSIONS: A tentative inverse association of circulating 25(OH)D with OC incidence was found, which did not reach statistical significance but which requires clarification by additional studies due to potentially high clinical and public health impact.

Research Highlights

►As we know, this is the first systematic review and meta-analysis evaluating the association between serum 25(OH)D levels and ovarian cancer risk.
►The method for comprehensive trend estimation from summarized dose–response data was used for combining all results from individual studies so far.
►A potential weak inverse association between serum vitamin D and ovarian cancer risk was found in this meta-analysis.