abstract: Familial Risks in Cancer of Unknown Primary: Tracking the Primary Sites Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Tuesday, April 19, 2011

abstract: Familial Risks in Cancer of Unknown Primary: Tracking the Primary Sites



Conclusion:

The present data show that CUP is not a disease of random metastatic cancers but, instead, a disease of a defined set of cancers. The association of CUP with families of kidney, lung, and colorectal cancers suggests a marked genetic basis and shared metastatic mechanisms by many cancer types. Familial sites shared by CUP generally match those arising in tissue-of-origin determinations and, hence, suggest sites of origin for CUP. Mechanistic exploration of CUP may provide insight into defense against primary tumors and the metastatic process.

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