BJC - Abstract: Breast, ovarian, and endometrial malignancies in systemic lupus erythematosus: a meta-analysis Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, April 23, 2011

BJC - Abstract: Breast, ovarian, and endometrial malignancies in systemic lupus erythematosus: a meta-analysis



Results:

  The five studies included 47325 SLE patients (42171 females) observed for 282553 patient years. There were 376 breast cancers, 66 endometrial cancers, and 44 ovarian cancers. The total number of cancers observed was less than that expected, with SIRs of 0.76 (95% CI: 0.69, 0.85) for breast cancer, 0.71 (95% CI: 0.55, 0.91) for endometrial cancer, and 0.66 (95% CI: 0.49, 0.90) for ovarian cancer.

Conclusions:

  Data strongly support a decreased risk of breast, ovarian, and endometrial cancers in SLE. This may be due to inherent differences in women in SLE (vs the general population) regarding endogenous oestrogen, other medications, and/or genetic make-up.

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