Results:
The five studies included 47 325 SLE patients (42 171 females) observed for 282 553
patient years. There were 376 breast cancers, 66 endometrial cancers,
and 44 ovarian cancers. The total number of cancers observed was less
than that expected, with SIRs of 0.76 (95% CI: 0.69, 0.85) for breast cancer, 0.71 (95% CI: 0.55, 0.91) for endometrial cancer, and 0.66 (95% CI: 0.49, 0.90) for ovarian cancer.
Conclusions:
Data
strongly support a decreased risk of breast, ovarian, and endometrial
cancers in SLE. This may be due to inherent differences in women in SLE (vs the general population) regarding endogenous oestrogen, other medications, and/or genetic make-up.
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