still recruiting: Study of Individuals/Families at High Risk for Breast or Ovarian Cancer...(Familial breast/ovarian Li-Fraumeni Peutz-Jegher Cowden....)

Criteria for Participation in this Clinical Trial          DISEASE CHARACTERISTICS:

• Any of the following:
• Families with neoplasias of an unusual type, pattern, or number, including breast cancer, or which is consistent with an identified or suspected familial cancer syndrome, including breast and/or ovarian cancer
• Families with a history of any of the following types of syndromes:
• Familial breast/ovarian
• Li-Fraumeni
• Peutz-Jegher
• Cowden
• Families with multiple cases of breast cancer among first- and second-degree relatives
• Families with a history of other cancers that do not fit into a well-characterized syndrome (e.g., multiple occurrences of breast and colorectal cancers)
• Families of an individual with a known mutation in the BRCA1 or BRCA2 gene
• Individuals with a personal history of neoplasia(s) or benign conditions of an unusual type
• Individuals with unusual demographic features, including:
• Young age at onset of disease
• Multiple primary sites
• Rare tumor type of pathologic characteristic
• At least 2 living affected family members are required for known or suspected familial syndromes for which no gene has been identified
• Diagnoses must be verifiable