repost (abstract) - Gynecologic Oncology : Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

Research highlights

► Lynch syndrome-associated ovarian cancer develops at early age (mean 48 years) with half of the tumors diagnosed at early stage and an overrepresentation of endometrioid (35%) and clear cell (17%) histologies.
► MMR gene mutations affect MSH2 in 49%, MSH6 in 33% and MLH1 in 17% with immunohistochemical loss of MMR protein staining in 92%