Gynecologic Oncology : The association between endometriosis and ovarian cancer: A review of histological, genetic and molecular alterations

.... PTEN play a part in the malignant transformation of endometriosis, some studies have revealed TP53 mutations in endometriotic lesions, and mutation of ARID1A (clear cell)

Highlights
► Atypical endometriosis is a transition from benign endometriosis to carcinoma.
► Endometriosis is characterized by genetic instability.
► Oxidative stress, inflammation and hyperestrogenism link endometriosis with cancer.