Revisiting the Role of Antiandrogen Strategies in Ovarian Cancer

link to abstract

selected excerpts (in efforts to understand the issues):

Epidemiological Data on Androgens and the Risk for EOC

In women, androgens are mainly synthesized in the adrenal glands, the ovaries, and adipose tissue, and they have an important physiological significance for bone and muscle growth and maintenance as well as cognitive function [1, 5]. There is a growing body of evidence supporting the notion that androgens influence proliferation of the normal ovarian epithelium and are a risk factor for EOC......

First, most clinical trials evaluating the use of androgen blockade for the treatment of EOC have been small, nonrandomized studies involving patients with platinum-resistant disease......
 
Third, most clinical trials assessing anti-AR strategies in EOC have not measured AR expression. The trials that did measure it used IHC, the results of which may not always reflect AR activity in EOC.