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International Journal of Gynecological Cancer:
January 2012 - Volume 22 - Issue 1 - p 43–46
doi: 10.1097/IGC.0b013e31823532ce
Ovarian Cancer
Extraperitoneal Metastases From Recurrent Ovarian Cancer
Robinson, William R. MD*; Beyer, Julie RN, BSN†; Griffin, Stephen MD†; Kanjanavaikoon, Paiyarut MD‡
Objectives: To identify patterns of metastasis in
patients with recurrent ovarian cancer. The influence of the route of
chemotherapy administration and sequence of agents on those patterns is
also examined.
Results: Thirty-five subjects developed
extraperitoneal recurrent ovarian cancer, with 26 subjects (74%) after
IP treatment, and 9 subjects (26%) after IV treatment. Of these
extraperitoneal recurrences, 26 were in the thoracic/pulmonary cavity, 7
were within the central nervous system (CNS), and 2 were in the
cutaneous tissues. The CNS and cutaneous lesions were secondary
recurrences, and all occurred in subjects who had initially received IP
cisplatin/paclitaxel followed by IV BEV for recurrent disease.
Conclusions: Extraperitoneal recurrences were more
common in women treated with IP chemotherapy for ovarian cancer.
Specifically, women treated with IV BEV as secondary therapy after IP
were at particularly high risk of extraperitoneal metastases, including
in the CNS and cutaneous tissues. Physicians should be aware of the
possibility of unusual metastases after the combination of IP
chemotherapy and BEV, and future prospective studies of this population
should carefully evaluate recurrence site patterns.
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