Jan 2012: Faulty proteins may prove significant in identifying new treatments for ovarian cancer | e! Science News Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, January 14, 2012

Jan 2012: Faulty proteins may prove significant in identifying new treatments for ovarian cancer | e! Science News



Link:  PLOS One published study


 Objective
To define the BRCAness profile of sporadic ovarian carcinoma and determine whether BRCA1, PARP, FANCD2, PTEN, H2AX, ATM, and P53 protein expression correlates with response to treatment, disease recurrence, and recurrence-free survival.

"The study -- which was supported by the Sherie Hildreth Ovarian Cancer (SHOC) Foundation -- focused on proteins that are supposed to assist cells in repairing harmful breaks in DNA strands, a process called homologous recombination (HR). The malfunctioning of HR is not well understood in ovarian cancers where there is no family history of the disease. However, there is evidence that these proteins influence a patient's ability to respond to drugs and their survival rates after treatment."

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