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"Close to 1.6 million new cases of cancer [1] and 64,530 primary brain tumors are expected to be diagnosed in the United States in 2011 [2]. The most common form of treatment for metastatic or primary tumors located in brain regions that are difficult to surgically remove continues to be whole brain radiation therapy (WBRT) [3]. Although this treatment regimen is effective in eliminating tumors, damage to normal brain tissue is inevitable. Several studies have shown that cognitive deficits occur in a relatively large percentage of brain tumor survivors, becoming evident months to years after treatment [3]–[6]......"
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