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Blog Archives: Nov 2004 - present
Special items: Ovarian Cancer and Us blog best viewed in Firefox
"Ovarian cancer, particularly endometrioid (cell type)adenocarcinoma, is also associated with Lynch syndrome.....Overall, 10% of tumors had abnormal MMR protein status, defined as
complete immunohistochemical loss of expression of MLH1, MSH2, MSH6,
and/or PMS2.....Concurrent uterine tumor was present in 5/7 patients whose ovarian tumor had abnormal MMR/MSI.......Although abnormal MMR/MSI did not carry prognostic value in this study,
it did predict the involvement of the uterus by the tumor. Thus, in
patients with ovarian endometrioid adenocarcinoma who undergo
uterus-sparing surgery, abnormal MMR/MSI should prompt further
diagnostic evaluation of the endometrium for tumor."
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