abstract: Pre-Treatment Tumor Expression of ERCC1 in Women with Advanced Stage Epithelial Ovarian Cancer is Not Predictive of Clinical Outcomes: A GOG study

Conclusions

ERCC1 expression, measured by IHC in pre-treatment tumor specimens, using a highly specific antibody, has limited clinical value in patients with advanced EOC treated with platinum and taxane based chemotherapy.

---

Highlights

► ERCC1 tumor expression in advanced EOC is not associated with patient survival.
► Common polymorphisms in ERCC1 were not associated with ERCC1 immunohistochemical expression.