BACKGROUND:
Germline mutations in the BRCA2
cancer susceptibility gene are associated with an increased risk of
pancreatic cancer (PC). Breast-pancreas cancer families with BRCA1 mutations have also been observed. The influence of a family history (FH) of PC on BRCA mutation prevalence in patients with breast cancer (BC) is unknown.
CONCLUSIONS:
BRCA1 and BRCA2
mutations are observed with nearly equal distribution in AJ
breast-pancreas cancer families, suggesting that both genes are
associated with PC risk. In this population, a FH of PC was found to
have a limited effect on mutation prevalence.
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