Prognostic significance of L1CAM in (serous) ovarian cancer and its role in constitutive NF-κB activation

Conclusions:
L1CAM expression contributes to the invasive and metastatic phenotype of serous ovarian carcinoma. L1CAM expression and shedding in the tumor microenvironment could contribute to enhanced invasion and tumor progression through increased IL-1β production and NF-κB activation.