JCO: Are Hematopoietic Colony-Stimulating Factors Over- or Underused? Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, February 27, 2012

JCO: Are Hematopoietic Colony-Stimulating Factors Over- or Underused?



Are Hematopoietic Colony-Stimulating Factors
Over- or Underused?


"Since their introduction, there has been debate about the benefits,
risks, and costs of hematopoietic colony-stimulating factors
(CSFs). We suggest that the use of CSFs to allow dose maintenance of
chemotherapy for common metastatic solid tumors is unsupported
by evidence, and we should reconsider using a $3,500-per-cycle injection
for a supportive care drug without major benefit......."



    [PDF]

    Table 1. Comparison of Major Guidelines 
     
    How Did We Arrive at Widespread Use Without
    Clinical Trial Justification?
     
    The Way Forward to Evidence-Based Use of CSFs

    "Increased concern about escalating costs 46-48 should cause us to
    examine each component of current care. Oncology professional societies have demanded some demonstrable improvement in an important outcome before adoption of a new technology.49 The lack of
    proven benefit from CSFs in support of therapy in common advanced
    solid tumors, the high cost, the disparate US and world use patterns
    with no difference in mortality, 50 and the potential for or appearance
    of economic self-interest should give the oncology community pause.
    There are concrete steps the US oncology community can take to
    foster more evidence-based care. The Quality Oncology Practice Initiative 51 could add overuse as a quality criterion 52 and report CSF use in palliative-intent regimens when there is less than a 20% risk of FN. The major guideline groups (European Organisation for Research and Treatment of Cancer,6 National Comprehensive Cancer Network,5
    and ASCO4) should endorse dose modification as an equally appropriate and preferred strategy in the absence of proven benefit."
     
     

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