lymphocytesplural of lym·pho·cyte
Noun: |
A form of small leukocyte (white blood cell) with a single round nucleus, occurring esp. in the lymphatic system. |
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Abstract (provisional)
Background
The immune system strongly influences outcome in patients with ovarian cancer. In particular, the absolute lymphocyte count in peripheral blood (ALC) and the presence of tumor-infiltrating lymphocytes (TIL) have each been associated with favourable prognosis. However, the mechanistic relationships between ALC, TIL and prognosis are poorly understood. We hypothesized that high ALC values might be associated with stronger tumor immunity as manifested by increased TIL, decreased tumor burden and longer survival.
Conclusions
Patients with high intrinsic ALC values show no clinical or survival advantage upon subsequent development of HGSC. ALC values at diagnosis are prognostic due to an association with disease burden rather than TIL. Therapeutic enhancement of ALC may be necessary but not sufficient to improve survival in HGSC.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
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